Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.
School of Bioscience and Technology, Weifang Medical University, Weifang, Shandong, China.
Adv Exp Med Biol. 2022;1377:153-161. doi: 10.1007/978-981-19-1592-5_12.
In previous chapters, we know that high-density lipoproteins (HDLs) could act at multiple cell lines and then trigger intracellular molecular pathway to prevent several metabolic diseases. Besides the classic genes regulating cholesterol efflux and reverse cholesterol transport (RCT), microRNAs (miRNAs) could also affect HDLs biogenesis, metabolism, and functions. This chapter summarizes the miRNAs, which regulate HDLs functions in table. In addition, HDLs are good vectors for miRNAs. They could carry miRNAs in circulation and take them into several cells such as macrophages and endothelial cells. Complete understanding of the miRNAs associated with HDL regulation would give us broader insights to prevent and treat metabolic diseases.
在前面的章节中，我们知道高密度脂蛋白（HDL）可以在多种细胞系中发挥作用，然后触发细胞内分子途径来预防多种代谢疾病。除了经典的调节胆固醇外排和胆固醇逆转运（RCT）的基因外，微小 RNA（miRNA）也可以影响 HDL 的生成、代谢和功能。本章总结了表中调节 HDL 功能的 miRNA。此外，HDL 是 miRNA 的良好载体。它们可以在循环中携带 miRNA，并将其带入巨噬细胞和内皮细胞等多种细胞。对与 HDL 调节相关的 miRNA 的全面了解将使我们更深入地了解预防和治疗代谢疾病的方法。
