McGoon M D, Vlietstra R E
Int J Cardiol. 1987 Mar;14(3):303-9. doi: 10.1016/0167-5273(87)90200-2.
The acute hemodynamic effect of intravenous ketanserin, an S2-serotonergic receptor antagonist, was evaluated during right heart catheterization in 20 patients with primary pulmonary hypertension. Pulmonary and systemic vascular resistance and pressure and cardiac output were measured before and after infusion of low and high dose ketanserin. A small decrease in pulmonary vascular resistance occurred after high dose drug infusion (28.4 to 25.0 U X m2; P less than 0.001), and mean pulmonary arterial pressure was unchanged. Decreases in systemic arterial pressure (91.9 to 85.9 mm Hg; P less than 0.0005) and systemic resistance (46.2 to 38.6 U X m2; P less than 0.001) were more pronounced. Cardiac index increased significantly (2.16 to 2.42 l/min/m2; P less than 0.01) due to reduced ventricular afterload. This study indicates that ketanserin has a small pulmonary vasodilating effect in primary pulmonary hypertension of doubtful clinical significance, similar to conventional vasodilators.
在20例原发性肺动脉高压患者进行右心导管插入术期间，评估了S2 - 血清素能受体拮抗剂静脉注射酮色林的急性血流动力学效应。在输注低剂量和高剂量酮色林之前和之后，测量了肺血管和体循环血管阻力、压力以及心输出量。高剂量药物输注后肺血管阻力出现小幅下降（从28.4降至25.0 U X m2；P小于0.001），而平均肺动脉压未改变。体循环动脉压（从91.9降至85.9 mmHg；P小于0.0005）和体循环阻力（从46.2降至38.6 U X m2；P小于0.001）的下降更为明显。由于心室后负荷降低，心脏指数显著增加（从2.16升至2.42 l/min/m2；P小于0.01）。本研究表明，酮色林在原发性肺动脉高压中具有轻微的肺血管舒张作用，临床意义存疑，与传统血管扩张剂类似。
