Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China.
College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211816, China.
Int J Biol Macromol. 2022 Jul 1;212:1-10. doi: 10.1016/j.ijbiomac.2022.05.084. Epub 2022 May 14.
Regenerated silk fibroin (RSF) hydrogels have been extensively studied in the fields of biomedicine and wearable devices in recent years due to their outstanding biocompatibility. However, the pure RSF hydrogels usually exhibited frangibility and low ductility, limiting their application in many aspects severely. Herein, we demonstrate a tough RSF/poly (N, N-dimethylallylamine) hydrogel with semi-interpenetrating network, which possesses good mechanical properties with high stretchability (ε = 900%), tensile strength (σ = 101.7 kPa), toughness (W = 516.7 kJ/m) and tearing fracture energy (T = 407.3 J/m). Besides, the gels show low residual strain in the cyclic tests and rapid self-recovery (80% toughness recovery within 5 min with the maximum strain of 400%). Moreover, the gels also show high ionic conductivity due to the incorporation of the NaCl and the hydrogel can act as an ideal candidate for strain sensor with high sensitivity (GF = 1.84), admirable linearity, and good durability (1000 cycles with the strain of 100%). When used as a wearable strain sensor for monitoring human movements, it also can detect small and large deformations with high sensitivity. It is expected that this work can provide a new strategy for the fabrication of smart RSF-based hydrogels and expand their application in multiple scenarios.
近年来，再生丝素蛋白（RSF）水凝胶因其出色的生物相容性而在生物医学和可穿戴设备领域得到了广泛研究。然而，纯 RSF 水凝胶通常易碎且延展性低，严重限制了其在许多方面的应用。在此，我们展示了一种具有半互穿网络的坚韧 RSF/聚（N，N-二甲基丙烯酰胺）水凝胶，具有良好的机械性能，具有高拉伸性（ε=900%）、拉伸强度（σ=101.7 kPa）、韧性（W=516.7 kJ/m）和撕裂断裂能（T=407.3 J/m）。此外，这些凝胶在循环测试中表现出低残余应变和快速自恢复（在最大应变 400%下，5 分钟内韧性恢复 80%）。此外，由于掺入 NaCl，这些水凝胶还具有较高的离子电导率，并且可以作为应变传感器的理想候选材料，具有高灵敏度（GF=1.84）、令人满意的线性度和良好的耐用性（在应变 100%下 1000 个循环）。当用作可穿戴应变传感器来监测人体运动时，它还可以以高灵敏度检测小变形和大变形。预计这项工作可为制造智能 RSF 基水凝胶提供一种新策略，并扩展其在多个场景中的应用。
