Liang Xiaoxu, Zhong Hai-Jing, Ding Hongyao, Yu Biao, Ma Xiao, Liu Xingyu, Chong Cheong-Meng, He Jingwei
School of Arts and Sciences, Guangzhou Maritime University, Guangzhou 510725, China.
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, China.
Polymers (Basel). 2024 Sep 29;16(19):2755. doi: 10.3390/polym16192755.
Polyvinyl alcohol (PVA)-based hydrogels have attracted significant attention due to their excellent biocompatibility, tunable mechanical properties, and ability to form stable three-dimensional networks. This comprehensive review explores the recent advancements in PVA-based hydrogels, focusing on their unique properties, fabrication strategies, and multifunctional applications. Firstly, it discusses various facile synthesis techniques, including freeze/thaw cycles, chemical cross-linking, and enhancement strategies, which have led to enhanced mechanical strength, elasticity, and responsiveness to external stimuli. These improvements have expanded the applicability of PVA-based hydrogels in critical areas such as biomedical, environmental treatment, flexible electronics, civil engineering, as well as other emerging applications. Additionally, the integration of smart functionalities, such as self-healing capabilities and multi-responsiveness, is also examined. Despite progress, challenges remain, including optimizing mechanical stability under varying conditions and addressing potential toxicity of chemical cross-linkers. The review concludes by outlining future perspectives, emphasizing the potential of PVA-based hydrogels in emerging fields like regenerative medicine, environmental sustainability, and advanced manufacturing. It underscores the importance of interdisciplinary collaboration in realizing the full potential of these versatile materials to address pressing societal challenges.
基于聚乙烯醇（PVA）的水凝胶因其优异的生物相容性、可调节的机械性能以及形成稳定三维网络的能力而备受关注。这篇综述探讨了基于PVA的水凝胶的最新进展，重点关注其独特性能、制备策略和多功能应用。首先，讨论了各种简便的合成技术，包括冻融循环、化学交联和增强策略，这些策略提高了机械强度、弹性以及对外部刺激的响应性。这些改进扩大了基于PVA的水凝胶在生物医学、环境处理、柔性电子、土木工程等关键领域以及其他新兴应用中的适用性。此外，还研究了智能功能的整合，如自愈能力和多响应性。尽管取得了进展，但挑战依然存在，包括在不同条件下优化机械稳定性以及解决化学交联剂的潜在毒性问题。综述最后概述了未来展望，强调了基于PVA的水凝胶在再生医学、环境可持续性和先进制造等新兴领域的潜力。它强调了跨学科合作对于充分发挥这些多功能材料的潜力以应对紧迫社会挑战的重要性。
