Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Virology Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Prostaglandins Other Lipid Mediat. 2022 Aug;161:106648. doi: 10.1016/j.prostaglandins.2022.106648. Epub 2022 May 13.
Maternal lipid metabolism status during pregnancy may have pivotal effects on a healthy pregnancy, the progression of labor, and childbirth. Based on evidence, changes in maternal lipid profile and metabolism is related to various alterations in fetal metabolic status, fat mass, birth weight and can result in serious maternal and fetal complications. 15-lipoxygenase accounts as a key enzyme in metabolizing polyunsaturated fatty acids that generate various inflammatory lipid metabolites. The possible involvement of 15- lipoxygenase and its metabolites in the inflammatory process, cell proliferation and death, and immune response has been postulated. The indicative role of the 15- lipoxygenase enzymatic pathway in the implantation process, stages of pregnancy, embryogenesis, organogenesis, progression of labor, pregnancy period, and pregnancy-associated complications is remarkable. Accordingly, this study will review the research conducted on the role of 15- lipoxygenase in different reproductive tissues, and its pathological role in pregnancy-related diseases to provide more insight regarding the emerging role of 15-lipoxygenase in normal pregnancy.
孕妇在怀孕期间的脂质代谢状态可能对健康妊娠、分娩过程和分娩有重要影响。有证据表明，母体脂质谱和代谢的变化与胎儿代谢状态、脂肪量、出生体重的各种变化有关，并可能导致严重的母婴并发症。15-脂氧合酶是代谢多不饱和脂肪酸的关键酶，可产生各种炎症性脂质代谢物。有人假设 15-脂氧合酶及其代谢物可能参与炎症过程、细胞增殖和死亡以及免疫反应。15-脂氧合酶酶促途径在着床过程、妊娠阶段、胚胎发生、器官发生、分娩进展、妊娠期间和与妊娠相关的并发症中的指示作用是显著的。因此，本研究将综述关于 15-脂氧合酶在不同生殖组织中的作用及其在与妊娠相关疾病中的病理作用的研究，以提供更多关于 15-脂氧合酶在正常妊娠中新兴作用的见解。
