内耳类器官：优势与局限
Inner Ear Organoids: Strengths and Limitations.
机构信息
Institute for Maternal and Child Health - I.R.C.C.S. "Burlo Garofolo", Trieste, Italy.
Inner Ear Stem Cell Lab, Department Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich and University of Zurich, USZ Campus WAGI18, Wagistrasse 18, 8952, Schlieren, Switzerland.
出版信息
J Assoc Res Otolaryngol. 2024 Feb;25(1):5-11. doi: 10.1007/s10162-024-00929-2. Epub 2024 Feb 9.
Inner ear organoids derived from differentiation of human pluripotent stem cells have recently gained momentum as tools to study inner ear development and developmental defects. An additional exciting aspect about this technology is represented by its translational potential, specifically, the use of organoids to validate therapeutics for hearing and balance restoration on human/patient-specific cells. This latter aspect will be briefly discussed here including opportunities and current limitations.
最近，源自人类多能干细胞分化的内耳类器官作为研究内耳发育和发育缺陷的工具得到了迅速发展。这项技术的另一个令人兴奋的方面是其转化潜力，特别是利用类器官来验证针对人类/患者特异性细胞的听力和平衡恢复治疗的方法。本文将简要讨论这一方面，包括其机遇和当前的局限性。
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