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Inner Ear Organoids: Strengths and Limitations.
J Assoc Res Otolaryngol. 2024 Feb;25(1):5-11. doi: 10.1007/s10162-024-00929-2. Epub 2024 Feb 9.
2
[Organoids-the key to novel therapies for the inner ear? German version].
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3
Human pluripotent stem cell-derived inner ear organoids recapitulate otic development in vitro.
Development. 2023 Oct 1;150(19). doi: 10.1242/dev.201865. Epub 2023 Oct 5.
4
Deafness-in-a-dish: modeling hereditary deafness with inner ear organoids.
Hum Genet. 2022 Apr;141(3-4):347-362. doi: 10.1007/s00439-021-02325-9. Epub 2021 Aug 3.
5
Recent Progress in Generation of Inner Ear Organoid.
Adv Biol (Weinh). 2024 Oct;8(10):e2400223. doi: 10.1002/adbi.202400223. Epub 2024 Jul 25.
6
Advancements in inner ear development, regeneration, and repair through otic organoids.
Curr Opin Genet Dev. 2022 Oct;76:101954. doi: 10.1016/j.gde.2022.101954. Epub 2022 Jul 16.
8
Generation of inner ear organoids containing functional hair cells from human pluripotent stem cells.
Nat Biotechnol. 2017 Jun;35(6):583-589. doi: 10.1038/nbt.3840. Epub 2017 May 1.
9
Directed Differentiation of Human Pluripotent Stem Cells into Inner Ear Organoids.
Methods Mol Biol. 2022;2520:135-150. doi: 10.1007/7651_2021_448.
10
Building inner ears: recent advances and future challenges for in vitro organoid systems.
Cell Death Differ. 2021 Jan;28(1):24-34. doi: 10.1038/s41418-020-00678-8. Epub 2020 Dec 14.

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Synthetically programming natural cell-cell communication pathways for tissue engineering.
Curr Opin Biomed Eng. 2024 Dec;32. doi: 10.1016/j.cobme.2024.100554. Epub 2024 Aug 24.
2
The rise of cochlear gene therapy.
Mol Ther. 2025 Jun 4;33(6):2343-2349. doi: 10.1016/j.ymthe.2024.11.012. Epub 2024 Nov 8.
3
Pharmacological Approaches to Hearing Loss.
Pharmacol Rev. 2024 Oct 16;76(6):1063-1088. doi: 10.1124/pharmrev.124.001195.

本文引用的文献

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Mapping oto-pharyngeal development in a human inner ear organoid model.
Development. 2023 Oct 1;150(19). doi: 10.1242/dev.201871. Epub 2023 Oct 5.
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Human pluripotent stem cell-derived inner ear organoids recapitulate otic development in vitro.
Development. 2023 Oct 1;150(19). doi: 10.1242/dev.201865. Epub 2023 Oct 5.
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Generating high-fidelity cochlear organoids from human pluripotent stem cells.
Cell Stem Cell. 2023 Jul 6;30(7):950-961.e7. doi: 10.1016/j.stem.2023.06.006.
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Defining developmental trajectories of prosensory cells in human inner ear organoids at single-cell resolution.
Development. 2023 Jun 15;150(12). doi: 10.1242/dev.201071. Epub 2023 Jun 29.
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A single-cell level comparison of human inner ear organoids with the human cochlea and vestibular organs.
Cell Rep. 2023 Jun 27;42(6):112623. doi: 10.1016/j.celrep.2023.112623. Epub 2023 Jun 7.
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Deafness: from genetic architecture to gene therapy.
Nat Rev Genet. 2023 Oct;24(10):665-686. doi: 10.1038/s41576-023-00597-7. Epub 2023 May 12.
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Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation.
Cell Stem Cell. 2023 May 4;30(5):571-591. doi: 10.1016/j.stem.2023.04.011.
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Fast and sensitive GCaMP calcium indicators for imaging neural populations.
Nature. 2023 Mar;615(7954):884-891. doi: 10.1038/s41586-023-05828-9. Epub 2023 Mar 15.
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Advances in gene therapy hold promise for treating hereditary hearing loss.
Mol Ther. 2023 Apr 5;31(4):934-950. doi: 10.1016/j.ymthe.2023.02.001. Epub 2023 Feb 8.
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CHD7 regulates otic lineage specification and hair cell differentiation in human inner ear organoids.
Nat Commun. 2022 Nov 17;13(1):7053. doi: 10.1038/s41467-022-34759-8.

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