Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milano, Italy; Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy.
Mouse and Animal Pathology Laboratory, Fondazione Unimi, Milano, Italy; Department of Veterinary Medicine and Animal Sciences, University of Milan, Lodi, Italy.
J Comp Pathol. 2022 Jun;194:34-38. doi: 10.1016/j.jcpa.2022.03.009. Epub 2022 Apr 26.
A 5-year-old female Springer Spaniel dog was submitted for necropsy after sudden death following vaccination against Leptospira spp. Gross examination revealed a diffuse dark red discolouration of skeletal musculature, severe diffuse congestion of all the abdominal organs and a contracted spleen. Severe dilation and reduction in wall width was seen in the right ventricle and histological examination revealed multifocal replacement of the right ventricular myocardium by a large amount of fibrofatty tissue. Pathological changes were consistent with post-vaccinal anaphylactic shock in a dog with arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare condition typical of Boxer dogs but not previously reported in Springer Spaniels. Canine vaccine-associated adverse events are discussed and ARVC is compared with the corresponding human cardiac condition.
一只 5 岁雌性史宾格犬在接种钩端螺旋体疫苗后突然死亡，随后被送检进行剖检。大体检查显示骨骼肌弥漫性暗红色变色，所有腹部器官严重弥漫性充血，脾脏收缩。右心室明显扩张，壁厚变薄，组织学检查显示右心室心肌被大量纤维脂肪组织替代。病变与致心律失常性右室心肌病（ARVC）犬的疫苗接种后过敏性休克一致，这是一种罕见的情况，典型于拳师犬，但以前未在史宾格犬中报道。讨论了犬疫苗相关不良事件，并将 ARVC 与相应的人类心脏疾病进行了比较。
