Yamada Naoaki, Kitamori Takashi, Kitamori Fumiyo, Ishigami Kanako, Iwanaga Koji, Itou Taiki, Kobayashi Ryosuke, Kumabe Shino, Doi Takuya, Sato Junko, Wako Yumi, Tsuchitani Minoru
Pathology Department, Kashima Laboratory, Nonclinical Research Center, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan.
J Vet Med Sci. 2015 Oct;77(10):1299-303. doi: 10.1292/jvms.14-0513. Epub 2015 May 8.
A 7-year-old female boxer dog died suddenly without any clinical signs. It was suspected that the dog had arrhythmogenic right ventricular cardiomyopathy (ARVC) due to ventricular premature complexes and ventricular tachycardia at 3 years of age. The final diagnosis of ARVC was confirmed by histological characteristics, such as loss of cardiocytes and fibrofatty replacement, occurring in the right and left ventricular walls. In the cardiocytes, non-lipid vacuoles were observed. Cardiac fibrosis and intimal thickening of the small arteries occurred without fatty replacement in the inner muscle layer including the papillary muscles of the left ventricular wall. This paper describes the pathomorphological details of an ARVC case with coincidental cardiac fibrosis in the inner muscle layer of the left ventricular wall.
一只7岁的雌性拳师犬突然死亡，生前无任何临床症状。该犬3岁时因室性早搏和室性心动过速被怀疑患有致心律失常性右室心肌病（ARVC）。通过组织学特征，如左右心室壁出现心肌细胞丢失和纤维脂肪替代，最终确诊为ARVC。在心肌细胞中观察到非脂质空泡。左心室壁包括乳头肌在内的内层肌肉出现心脏纤维化和小动脉内膜增厚，但无脂肪替代。本文描述了一例左心室壁内层肌肉合并心脏纤维化的ARVC病例的病理形态学细节。
