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团体治疗复杂分离性障碍:一项随机临床试验。

Group treatment for complex dissociative disorders: a randomized clinical trial.

机构信息

Research Institute, Modum Bad Psychiatric Hospital, Vikersund, Norway.

Section for Implementation and Treatment Research, Norwegian Center for Violence and Traumatic Stress Studies, Oslo, Norway.

出版信息

BMC Psychiatry. 2022 May 16;22(1):338. doi: 10.1186/s12888-022-03970-8.

Abstract

BACKGROUND

Patients with complex dissociative disorders (CDD) report high levels of childhood- abuse experiences, clinical comorbidity, functional impairment, and treatment utilization. Although a few naturalistic studies indicate that these patients can benefit from psychotherapy, no randomized controlled trials have been reported with this patient-group. The current study evaluates a structured protocolled group treatment delivered in a naturalistic clinical setting to patients with CDD, as an add-on to individual treatment.

METHODS

Fifty nine patients with CDD were randomized to 20 sessions of stabilizing group-treatment, conjoint with individual therapy, or individual therapy alone, in a delayed-treatment design. The treatment was based on the manual Coping with Trauma-Related Dissociation. The primary outcome was Global Assessment of Functioning (GAF), while secondary outcomes were PTSD and dissociative symptoms, general psychopathology, and interpersonal difficulties.

RESULTS

Mixed effect models showed no condition x time interaction during the delayed treatment period, indicating no immediate differences between conditions in the primary outcome. Similar results were observed for secondary outcomes. Within-group effects were non-significant in both conditions from baseline to end of treatment, but significant improvements in psychosocial function, PTSD symptoms, and general psychopathology were observed over a 6-months follow-up period.

CONCLUSION

In the first randomized controlled trial for the treatment of complex dissociative disorders, stabilizing group treatment did not produce immediate superior outcomes. Treatment was shown to be associated with improvements in psychological functioning.

TRIAL REGISTRATION

Clinical Trials ( NCT02450617 ).

摘要

背景

患有复杂分离障碍(CDD)的患者报告有较高水平的童年虐待经历、临床共病、功能障碍和治疗利用情况。尽管一些自然主义研究表明,这些患者可以从心理治疗中受益,但尚未有针对该患者群体的随机对照试验报告。本研究评估了一种结构化的协议小组治疗,在自然临床环境中作为个体治疗的附加治疗,用于 CDD 患者。

方法

59 名患有 CDD 的患者被随机分配到 20 节稳定小组治疗中,与个体治疗联合使用,或单独进行个体治疗,采用延迟治疗设计。该治疗基于《应对创伤相关分离手册》。主要结果是总体功能评估(GAF),次要结果是创伤后应激障碍和分离症状、一般精神病理学和人际关系困难。

结果

混合效应模型显示,在延迟治疗期间,条件与时间之间没有交互作用,表明在主要结果方面,条件之间没有立即的差异。次要结果也观察到类似的结果。在两种条件下,从基线到治疗结束,组内效应均不显著,但在 6 个月的随访期间,心理社会功能、创伤后应激障碍症状和一般精神病理学均有显著改善。

结论

在治疗复杂分离障碍的首次随机对照试验中,稳定小组治疗并没有产生立即的优势结果。治疗与心理功能的改善有关。

试验注册

临床试验(NCT02450617)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36b0/9112598/cd15c67ec659/12888_2022_3970_Fig1_HTML.jpg

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