Huntjens Rafaële J C, Rijkeboer Marleen M, Arntz Arnoud
Department of Experimental Psychotherapy and Psychopathology, University of Groningen, Groningen, the Netherlands.
Department of Clinical Psychological Science, Maastricht University, Maastricht, the Netherlands.
Eur J Psychotraumatol. 2019 Feb 14;10(1):1571377. doi: 10.1080/20008198.2019.1571377. eCollection 2019.
: A category of disorders frequently associated with a history of trauma are the dissociative disorders, of which Dissociative Identity Disorder (DID) is the most severe and chronic form. DID is associated with high levels of impairment, treatment utilization, and treatment costs, yet systematic research into treatment effects is scarce. Practice-based clinical guidelines advise a phase-based approach which is lengthy and has rather high reported dropout rates. Therefore, in the current proposal the efficacy of an alternative treatment for DID (i.e. schema therapy) is tested. : The aim of this study is to critically test the effectiveness of schema therapy for DID patients, for whom at present no evidence-based treatment is available. : In light of the low prevalence of DID, and the proposed treatment length of three years, a case series experimental approach is used (non-concurrent multiple baseline design). Ten outpatients are included, who are diagnosed with DID by an independent rater using the Structured Clinical Interview for DSM-IV Dissociative Disorders (SCID-D-R), which is double-checked by another independent expert. Primary outcomes are a (bi)weekly assessed state measure of dissociative symptoms, a pre-, post- and follow-up measure of the presence of the DID diagnosis, and drop-out rate. Secondary outcomes include various measures of trait dissociative symptoms, comorbid symptomatology, and global symptomatic distress. : Netherlands Trial Register (NTR): NTR4496.
一类常与创伤史相关的障碍是分离性障碍,其中分离性身份识别障碍(DID)是最严重和慢性的形式。DID与高水平的功能损害、治疗利用和治疗成本相关,但对治疗效果的系统研究却很匮乏。基于实践的临床指南建议采用分阶段方法,该方法耗时较长且报告的脱落率相当高。因此,在当前的提议中,对DID的一种替代治疗方法(即图式疗法)的疗效进行了测试。
本研究的目的是严格检验图式疗法对DID患者的有效性,目前尚无针对这些患者的循证治疗方法。
鉴于DID的低患病率以及提议的三年治疗时长,采用了病例系列实验方法(非同期多重基线设计)。纳入了10名门诊患者,他们由一名独立评估者使用《精神疾病诊断与统计手册》第四版分离性障碍结构化临床访谈(SCID-D-R)诊断为DID,并由另一名独立专家进行复核。主要结局指标是每(两)周评估一次的分离症状状态测量、DID诊断存在情况的治疗前、治疗后及随访测量,以及脱落率。次要结局指标包括特质分离症状、共病症状学和整体症状困扰的各种测量。
荷兰试验注册编号(NTR):NTR4496。