Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul. Porto Alegre RS, Brazil.
Integrated Oncology Center, Hospital Ana Nery. Santa Cruz do Sul - RS, Brasil.
J Mycol Med. 2022 Aug;32(3):101292. doi: 10.1016/j.mycmed.2022.101292. Epub 2022 May 3.
Paracoccidoidomycosis (PCM) is a granulomatous systemic mycosis endemic in southern Brazil.
Analyze the clinical and epidemiological characteristics of cases of PCM with head and neck manifestations in southern Brazil.
Retrospective study of histopathologically diagnosed cases of PCM with head and neck manifestations referred to two medical centers in the municipality of Santa Cruz do Sul, state of Rio Grande do Sul, Brazil, during a 10-year period (2011-2020).
Twenty-eight patients were selected. The number of cases usually ranged from one to four per year, although 11 cases were diagnosed in 2019. Most patients were between 40 and 59 years old. In total, 21 patients were men and seven were women (male:female ratio 3:1). Most (92%) were Caucasian and 46% were smokers. Patients were from 12 municipalities in the central-eastern region of the state. The most frequent site of the lesions was the larynx. Associated HIV and squamous cell carcinoma were both present in three cases.
This is the first study to analyze PCM cases from central-eastern Rio Grande do Sul. PCM is endemic in southern Brazil, and more epidemiological data are needed, considering that its incidence may be higher than currently estimated, as demonstrated by our results.
球孢子菌病（PCM）是一种在巴西南部流行的肉芽肿性系统性真菌病。
分析巴西南部头颈部表现的 PCM 病例的临床和流行病学特征。
对巴西南里奥格兰德州圣克鲁斯杜斯库尔斯市的两家医疗中心在 10 年间（2011-2020 年）收治的经组织病理学诊断为头颈部表现的 PCM 病例进行回顾性研究。
共选择了 28 例患者。每年的病例数通常在 1 到 4 例之间，但 2019 年诊断出 11 例。大多数患者年龄在 40 到 59 岁之间。共有 21 例男性和 7 例女性（男女比例为 3:1）。大多数（92%）患者为白种人，46%为吸烟者。患者来自该州中东部的 12 个市镇。病变最常见的部位是喉。在三种情况下，同时存在艾滋病毒感染和鳞状细胞癌。
这是首次分析来自南里奥格兰德州中东部的 PCM 病例。PCM 在巴西南部流行，需要更多的流行病学数据，考虑到其发病率可能高于目前的估计，这从我们的结果中可以看出。
