Identification of novel erythromycin derivatives in mother liquor concentrates of Streptomyces erythraeus.
作者信息
Kibwage I O, Janssen G, Busson R, Hoogmartens J, Vanderhaeghe H, Verbist L
出版信息
J Antibiot (Tokyo). 1987 Jan;40(1):1-6. doi: 10.7164/antibiotics.40.1.
PMID:3558111
Abstract
The identification of five novel compounds, pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-erythromycin A-6,9-hemiketal, 8,9-anhydro-pseudo-N-demethylerythromycin A-6,9-hemiketal, 5-O-beta-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13----C11 trans-lactonization. The five compounds have very little antimicrobial activity.
摘要
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