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“真实世界”中挽救性鼓室内类固醇治疗突发性聋后临床显著听力恢复的概率。

Probability of clinically significant hearing recovery following salvage intratympanic steroids for sudden sensorineural hearing loss in the 'real world'.

机构信息

Department of Otolaryngology and Head and Neck Surgery, Lauriston Building, Edinburgh, Scotland, UK.

出版信息

J Laryngol Otol. 2022 Sep;136(9):831-838. doi: 10.1017/S0022215122001062. Epub 2022 May 18.

Abstract

OBJECTIVE

This study aimed to determine the probability of hearing recovery in patients with idiopathic sudden sensorineural hearing loss following salvage intratympanic steroids.

METHOD

A retrospective review of all patients receiving salvage intratympanic steroid injections for idiopathic sudden sensorineural hearing loss was performed (January 2014 to December 2019). Twenty-two patients were identified, of whom 15 met inclusion criteria. Pre- and post-treatment audiograms were compared with the unaffected ear. Hearing recovery was categorised based on American Academy of Otolaryngology Head and Neck Surgery criteria.

RESULTS

Only 1 patient out of 15 (6.7 per cent) made a partial recovery, and the remainder were non-responders. The median duration of time between symptom onset and first salvage intratympanic steroid treatment was 52 days (range, 14-81 days). No adverse reactions were observed.

CONCLUSION

'Real world' patients with idiopathic sudden sensorineural hearing loss present differently to those in the literature. Sudden sensorineural hearing loss should be diagnosed with care and intratympanic steroid injections initiated early if considered appropriate. Patients should make an informed decision on treatment based on prognostic factors and local success rates.

摘要

目的

本研究旨在确定接受挽救性鼓室内类固醇治疗的特发性突发性聋患者的听力恢复概率。

方法

对所有接受挽救性鼓室内类固醇注射治疗的特发性突发性聋患者进行回顾性分析(2014 年 1 月至 2019 年 12 月)。共确定了 22 例患者,其中 15 例符合纳入标准。比较治疗前后的听阈与对侧正常耳。根据美国耳鼻喉科学会头颈部外科学会的标准对听力恢复进行分类。

结果

15 例患者中仅 1 例(6.7%)部分恢复,其余均无反应。症状发作至首次挽救性鼓室内类固醇治疗的中位时间为 52 天(范围,14-81 天)。未观察到不良反应。

结论

“真实世界”中的特发性突发性聋患者与文献中的患者表现不同。突发性聋应谨慎诊断,如果认为合适,应尽早开始鼓室内类固醇注射治疗。患者应根据预后因素和当地成功率做出知情治疗决策。

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