Conciatori Fabiana, Bazzichetto Chiara, Falcone Italia, Ferretti Gianluigi, Cognetti Francesco, Milella Michele, Ciuffreda Ludovica
Medical Oncology 1, IRCCS - Regina Elena National Cancer Institute, Rome 00144, Italy.
Section of Oncology, Department of Medicine, University of Verona School of Medicine and Verona University Hospital Trust, Verona 37126, Italy.
Cancer Drug Resist. 2019 Dec 19;2(4):968-979. doi: 10.20517/cdr.2019.56. eCollection 2019.
Colorectal cancer (CRC) still remains a disease with high percentage of death, principally due to therapy resistance and metastasis. During the time the hypothesis has been reinforced that CRC stem cells (CRCSC) are involved in allowing intratumoral heterogeneity, drug escape mechanisms and secondary tumors. CRCSC are characterized by specific surface markers (i.e., CD44 and CD133), signaling pathways activation (i.e., Wnt and Notch) and gene expression (i.e., Oct4 and Snail), which confer to CRCSC self-renewal abilities and pluripotent capacity. Interleukin (IL)-8 is correlated to CRC progression, development of liver metastases and chemoresistance; moreover, IL-8 modulates not only stemness maintenance but also stemness promotion, such as epithelial-mesenchymal transition. This review wants to give a brief and up-to-date overview on IL-8 implication in CRCSC cues.
结直肠癌（CRC）仍然是一种死亡率很高的疾病，主要原因是治疗耐药性和转移。在此期间，有假设得到了进一步强化，即结直肠癌干细胞（CRCSC）参与导致肿瘤内异质性、药物逃逸机制和继发性肿瘤。CRCSC的特征在于特定的表面标志物（如CD44和CD133）、信号通路激活（如Wnt和Notch）以及基因表达（如Oct4和Snail），这些赋予了CRCSC自我更新能力和多能性。白细胞介素（IL）-8与CRC进展、肝转移的发生和化疗耐药性相关；此外，IL-8不仅调节干性维持，还调节干性促进，如上皮-间质转化。本综述旨在对IL-8在CRCSC信号中的作用进行简要的最新概述。
