Chen Xueru, Zhang Ruibin, Xie Hui, Li Sha, Guo Jincai, Wang Yan
Department of Pharmacy, Changsha Stomatological Hospital, Changsha, China.
School of Stomatology, Hunan University of Chinese Medicine, Changsha, China.
Front Oncol. 2025 Mar 6;15:1543182. doi: 10.3389/fonc.2025.1543182. eCollection 2025.
To evaluate the possible association of the cytokine polymorphisms with the risk of nasopharyngeal carcinoma (NPC).
We performed a comprehensive search of electronic databases from PubMed, Web of Science, Embase, and CNKI. Articles related to the cytokine polymorphisms in patients with NPC and healthy controls from inception to 1 April 2024 were included. The results were analysed independently by two reviewers using RevMan 5.4 software. Summary odds ratio (OR) and 95% confidence interval (CI) were used to evaluate cancer risk.
Our results showed that IL-10 1082A>G showed a significant difference only in the Dominant model, but in the Asian population, a significant difference was shown in all models. IL-18 607C>A polymorphism showed significant differences in the Allele model, Heterozygote model, and Homozygote model. In addition, the IL-18 137G>C polymorphism showed significant differences in all models. No statistically significant association was found between IL-8 251A>T, IL-10 819T>C polymorphism, and the risk of NPC.
Our meta-analysis results suggest that the IL-18 607C>A and IL-18 137G>C polymorphism are associated with the increased risk of NPC, and IL-10-1082 A/G polymorphism is associated with the increased risk of NPC in Asian populations.
评估细胞因子多态性与鼻咽癌（NPC）风险之间的可能关联。
我们对来自PubMed、Web of Science、Embase和中国知网的电子数据库进行了全面检索。纳入了从创刊至2024年4月1日的有关NPC患者和健康对照中细胞因子多态性的文章。由两名审阅者使用RevMan 5.4软件独立分析结果。采用汇总比值比（OR）和95%置信区间（CI）来评估癌症风险。
我们的结果显示，IL-10 1082A>G仅在显性模型中显示出显著差异，但在亚洲人群中，在所有模型中均显示出显著差异。IL-18 607C>A多态性在等位基因模型、杂合子模型和纯合子模型中显示出显著差异。此外，IL-18 137G>C多态性在所有模型中均显示出显著差异。未发现IL-8 251A>T、IL-10 819T>C多态性与NPC风险之间存在统计学显著关联。
我们的荟萃分析结果表明，IL-18 607C>A和IL-18 137G>C多态性与NPC风险增加相关，而IL-10 - 1082 A/G多态性与亚洲人群中NPC风险增加相关。
