Choi WonSeok William, Boland Julia L, Lin Jianqing
Division of Hematology/Oncology and Department of Medicine, George Washington University Hospital, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA.
Cancer Drug Resist. 2022 Feb 8;5(1):165-170. doi: 10.20517/cdr.2021.108. eCollection 2022.
Despite androgen dependence in a majority of castration-resistant prostate cancers, some cancer cells are independent of androgen receptor (AR) function, a feature of heterogeneity in prostate cancer. One of the aggressive variants of prostate cancer that are AR independent is neuroendocrine prostate cancer (NEPC). This manuscript will focus on the new finding of human one cut domain family member 2 (ONECUT2) transcription factor and its role in castration resistance, especially in NEPC.
尽管大多数去势抵抗性前列腺癌依赖雄激素，但一些癌细胞独立于雄激素受体（AR）功能，这是前列腺癌异质性的一个特征。前列腺癌中一种侵袭性较强且不依赖AR的变体是神经内分泌前列腺癌（NEPC）。本手稿将聚焦于人类单切割域家族成员2（ONECUT2）转录因子的新发现及其在去势抵抗中的作用，尤其是在NEPC中的作用。
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