Department of Medical Humanities, Julius Center for Health Sciences & Primary Care, University Medical Center Utrecht, Utrecht, 3508, GA, The Netherlands.
Department of Human Genetics & Interdisciplinary Stem Cell Institute, Dr. John T. Macdonald Foundation, University of Miami Miller School of Medicine, Miami, FL 3310, USA.
Regen Med. 2022 Jul;17(7):445-459. doi: 10.2217/rme-2022-0019. Epub 2022 May 17.
The perspectives of researchers and patients regarding roles and responsibilities in stem cell research are rarely studied, but these could offer insights about responsible research conduct. We have conducted a qualitative study consisting of focus groups with both early- (n = 7) and late-career stem cell researchers (n = 11) that are primarily based in Europe, and with Dutch patients with chronic lower back pain (n = 9). These focus groups have been analyzed thematically. Four themes were identified: 1) roles and responsibilities in the laboratory, 2) responsibilities of and toward patients and the public, 3) the role of regulation and 4) structural hurdles for responsibility. The results suggest that responsible research conduct could be improved by addressing grant application procedures, publication pressure and by providing support of dissemination activities for researchers. Responsibility in stem cell research could be enhanced by embracing open science initiatives and targeted training.
研究人员和患者对于干细胞研究中角色和责任的看法很少被研究，但这些看法可以为负责任的研究行为提供一些启示。我们进行了一项定性研究，包括在欧洲的早期（n=7）和晚期职业生涯的干细胞研究人员（n=11）的焦点小组，以及荷兰慢性下腰痛患者（n=9）的焦点小组。这些焦点小组已经进行了主题分析。确定了四个主题：1）实验室中的角色和责任，2）对患者和公众的责任，3）监管的作用，4）责任的结构障碍。结果表明，通过解决拨款申请程序、出版压力以及为研究人员提供传播活动的支持，可以改善负责任的研究行为。通过接受开放科学倡议和有针对性的培训，可以提高干细胞研究中的责任感。
