Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience & Human Behavior, University of California Los Angeles, Los Angeles, CA 90024, USA.
Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90024, USA.
CNS Oncol. 2022 Jun 1;11(2):CNS84. doi: 10.2217/cns-2022-0002. Epub 2022 May 18.
Understanding and supporting quality of life (QoL) and daily functioning in glioma patients is a clinical imperative. In this study, we examined the relationship between cognition, psychological factors, measures of health-related QoL and functioning in glioma survivors. We examined neuropsychological, self-reported cognition, mood and QoL correlates of work and non-work-related daily functioning in 23 glioma survivors, and carried out linear models of the best predictors. A total of 13/23 participants were working at the time of enrollment. The best model for worse work-related functioning (R = .83) included worse self-reported cognitive function, depression, loneliness and brain tumor symptoms. The best model for worse non-work-related functioning (R = .61) included worse self-reported cognitive functioning, anxiety, sleep disturbance and physical functioning. Neuropsychological variables were not among the most highly correlated with function. Worse cognitive, particularly self-reported and psychosocial outcomes may compromise optimal functioning in glioma survivors.
了解和支持胶质瘤患者的生活质量（QoL）和日常功能是临床的当务之急。在这项研究中，我们研究了认知、心理因素、与健康相关的生活质量和功能测量之间的关系在 23 名胶质瘤幸存者中，我们检查了与工作和非工作相关的日常功能相关的神经心理学、自我报告认知、情绪和生活质量，并进行了最佳预测因子的线性模型。在入组时，共有 13/23 名参与者正在工作。更差的工作相关功能（R=0.83）的最佳模型包括较差的自我报告认知功能、抑郁、孤独和脑瘤症状。更差的非工作相关功能（R=0.61）的最佳模型包括较差的自我报告认知功能、焦虑、睡眠障碍和身体功能。神经心理学变量并不是与功能相关性最高的变量之一。更差的认知，特别是自我报告和社会心理结果，可能会影响胶质瘤幸存者的最佳功能。
