Stem Cells, Canadian Blood Services, Ottawa, Ontario, Canada.
Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Vox Sang. 2022 Sep;117(9):1121-1125. doi: 10.1111/vox.13294. Epub 2022 May 18.
Understanding changes in the demand and usage of unrelated allogeneic haematopoietic cell transplantation (HCT) donors during the COVID-19 pandemic is needed to optimize pandemic preparedness of registry and donor collection services. The aim of this study was to understand the extent to which the pandemic has impacted the demand and usage of unrelated donors and cord blood units (CBUs) at Canadian Blood Services (CBS).
Data regarding stem cell donor interest and product usage for unrelated allogeneic HCT were retrieved from the database at CBS using de-identified anonymous information.
Unrelated donor searches for Canadian patients remained unchanged by the pandemic, reflecting stable demand. The number of unrelated allogeneic transplants performed within Canada also remained stable, while the number of cord blood transplants increased, chiefly for paediatric patients. Requests for donor verification typing, a first signal of potential interest, increased from domestic centres during the first 6 months of the pandemic and decreased from international centres, before returning to baseline levels. The proportion of transplants for Canadian patients who used stem cell products procured from Canadian donors increased between 3 and 6 months after the start of the pandemic before returning to baseline and appears to be increasing again more than 1 year after the start of the pandemic. Use of CBUs for Canadian paediatric patients increased and remains elevated.
Demand for unrelated adult HCT donors has remained stable despite the evolving pandemic with a transient and recurring increased interest and usage of domestic adult donors. Use of CBUs for paediatric patients has increased and remains elevated. Registries and donor collection centres should maintain the capacity to expand services for domestic donor collection during pandemics to offset threats to international donor usage.
了解 COVID-19 大流行期间无关供者异基因造血细胞移植（HCT）需求和使用的变化，对于优化登记处和供者采集服务的大流行防范至关重要。本研究旨在了解大流行对加拿大血液服务中心（CBS）无关供者和脐血单位（CBU）的需求和使用产生的影响程度。
使用 CBS 数据库中经过去识别匿名处理的信息，检索有关无关供者异基因 HCT 干细胞供者兴趣和产品使用的数据。
加拿大患者对无关供者的搜索在大流行期间保持不变，反映出需求稳定。加拿大境内进行的无关异体移植数量也保持稳定，而脐血移植数量增加，主要是为儿科患者进行的。供者验证检测请求（潜在兴趣的第一个信号）在大流行的前 6 个月内从国内中心增加，从国际中心减少，然后恢复到基线水平。在大流行开始后的 3 至 6 个月内，用于加拿大患者的移植中使用从加拿大供者获得的干细胞产品的比例增加，然后恢复到基线水平，并且似乎在大流行开始 1 年多后再次增加。用于加拿大儿科患者的 CBU 使用增加且保持较高水平。
尽管大流行不断演变，但无关成人 HCT 供者的需求保持稳定，国内成人供者的兴趣和使用呈现短暂且反复增加的趋势。用于儿科患者的 CBU 使用增加且保持较高水平。在大流行期间，登记处和供者采集中心应保持扩大国内供者采集服务的能力，以抵消对国际供者使用的威胁。
