College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China.
Food Funct. 2022 Jun 6;13(11):5914-5924. doi: 10.1039/d2fo00226d.
NISSLE 1917 (EcN) is a Gram-negative strain with many prominent probiotic properties in the treatment of intestinal diseases such as diarrhea and inflammatory bowel disease (IBD), in particular ulcerative colitis. EcN not only exhibits antagonistic effects on a variety of intestinal pathogenic bacteria, but also regulates the secretion of immune factors and enhances the ability of host immunity. In this review, the mechanisms of EcN in the remission of inflammatory bowel disease are proposed and recent advances on the functionalized EcN are compiled to provide novel therapeutic strategies for the prevention and treatment of IBD.
NISSLE 1917（EcN）是一种革兰氏阴性菌株，具有许多突出的益生菌特性，可用于治疗腹泻和炎症性肠病（IBD）等肠道疾病，特别是溃疡性结肠炎。EcN 不仅对多种肠道致病菌表现出拮抗作用，还调节免疫因子的分泌，增强宿主免疫力。本文提出了 EcN 在缓解炎症性肠病中的作用机制，并对功能化 EcN 的最新进展进行了综述，为 IBD 的防治提供了新的治疗策略。
