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探索一条充满挑战的道路：使用定制的口服纳米装甲益生菌进行精准疾病治疗。

Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics.

作者信息

Chen Anmei, Gong Ying, Wu Shaoquan, Du Ye, Liu Zhijun, Jiang Yuhong, Li Jiahong, Miao Yang-Bao

机构信息

School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610041, China.

Department of Haematology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine of University of Electronic Science and Technology of China, No. 32, West Section 2, First Ring Road, Qingyang District, Chengdu, 610000, China.

出版信息

J Nanobiotechnology. 2025 Feb 1;23(1):72. doi: 10.1186/s12951-025-03141-3.

DOI:10.1186/s12951-025-03141-3
PMID:39893419
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11786591/
Abstract

Oral probiotics have significant potential for preventing and treating many diseases. Yet, their efficacy is often hindered by challenges related to survival and colonization within the gastrointestinal tract. Nanoparticles emerge as a transformative solution, offering robust protection and enhancing the stability and bioavailability of these probiotics. This review explores the innovative application of nanoparticle-armored engineered probiotics for precise disease treatment, specifically addressing the physiological barriers associated with oral administration. A comprehensive evaluation of various nano-armor probiotics and encapsulation methods is provided, carefully analyzing their respective merits and limitations, alongside strategies to enhance probiotic survival and achieve targeted delivery and colonization within the gastrointestinal tract. Furthermore, the review explores the potential clinical applications of nano-armored probiotics in precision therapeutics, critically addressing safety and regulatory considerations, and proposing the innovative concept of 'probiotic intestinal colonization with nano armor' for brain-targeted therapies. Ultimately, this review aspires to guide the advancement of nano-armored probiotic therapies, driving progress in precision medicine and paving the way for groundbreaking treatment modalities.

摘要

口服益生菌在预防和治疗多种疾病方面具有巨大潜力。然而，它们的功效常常受到与在胃肠道内存活和定殖相关挑战的阻碍。纳米颗粒作为一种变革性解决方案出现，为这些益生菌提供强大保护，并提高其稳定性和生物利用度。本综述探讨了纳米颗粒包裹的工程益生菌在精准疾病治疗中的创新应用，特别针对口服给药相关的生理屏障。提供了对各种纳米包裹益生菌和包封方法的全面评估，仔细分析了它们各自的优缺点，以及提高益生菌存活率并在胃肠道内实现靶向递送和定殖的策略。此外，本综述探讨了纳米包裹益生菌在精准治疗中的潜在临床应用，批判性地讨论了安全性和监管方面的考虑因素，并提出了“纳米铠甲益生菌肠道定殖”用于脑靶向治疗的创新概念。最终，本综述旨在指导纳米包裹益生菌疗法的发展，推动精准医学的进步，并为开创性的治疗方式铺平道路。

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