Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Department of Analytic Human Pathology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Hum Vaccin Immunother. 2022 Nov 30;18(5):2071080. doi: 10.1080/21645515.2022.2071080. Epub 2022 May 18.
Following COVID-19 vaccination, ipsilateral axillary and cervical lymphadenopathy may occur, called vaccine-related hypermetabolic lymphadenopathy, which is considered reactive lymphadenopathy. We report here a case of Kikuchi-Fujimoto disease, which occurred three months after vaccination with COVID-19 vaccine. The patient had cervical and axillary lymph node enlargement and a short-term fever that resolved spontaneously after the first and second vaccines. On the 90th day after the first vaccination, the patient developed a high fever and pathologically diagnosed necrotizing lymphadenitis in the axilla, which was diagnosed as Kikuchi-Fujimoto disease. Gallium scintigraphy showed localized swelling and strong uptake in the ipsilateral axilla. It implies the possibility of Kikuchi-Fujimoto Disease in axillary drainage lymph nodes in association with COVID-19 vaccine. Although only a few cases have been reported so far, this case is novel because of its later onset and diagnosis based on pathological and gallium scintigraphy imaging findings.
接种 COVID-19 疫苗后，可能会发生同侧腋窝和颈部淋巴结病，称为疫苗相关高代谢性淋巴结病，被认为是反应性淋巴结病。我们在此报告一例 COVID-19 疫苗接种后三个月发生的 Kikuchi-Fujimoto 病。患者出现颈、腋窝淋巴结肿大和短期发热，在接种第一和第二剂疫苗后自发消退。在第一次接种后第 90 天，患者出现高热，腋窝病理诊断为坏死性淋巴结炎，诊断为 Kikuchi-Fujimoto 病。镓闪烁显像显示同侧腋窝局部肿胀和摄取增强。这提示 COVID-19 疫苗接种后与腋窝引流淋巴结相关的 Kikuchi-Fujimoto 病的可能性。尽管到目前为止只有少数病例报道，但由于其发病较晚，且基于病理和镓闪烁显像影像学发现进行诊断，因此该病例具有新颖性。
