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纵向混合方法研究积极健康检查:1 型有效性-实施混合试验的实施结果。

A Longitudinal Mixed-Methods Examination of Positive Health Check: Implementation Results From a Type 1 Effectiveness-Implementation Hybrid Trial.

机构信息

RTI International, Research Triangle Park, NC; and.

Centers for Disease Control and Prevention, Division of HIV Prevention, Atlanta, GA.

出版信息

J Acquir Immune Defic Syndr. 2022 Sep 1;91(1):47-57. doi: 10.1097/QAI.0000000000003018. Epub 2022 May 18.

Abstract

BACKGROUND

Positive Health Check is an evidence-based video doctor intervention developed for improving the medication adherence, retention in care, and viral load suppression of people with HIV receiving clinical care.

SETTING

Four HIV primary care clinics within the United States.

METHODS

As part of a type 1 hybrid trial, a mixed-methods approach was used to longitudinally assess the following 3 key implementation constructs over a 23-month period: innovation-values fit (ie, the extent to which staff perceive innovation use will foster the fulfillment of their values), organizational readiness for change (ie, the extent to which organizational members are psychologically and behaviorally prepared to implement organizational change), and implementation climate (ie, the extent to which implementation is expected, supported, and rewarded). Quantitative mixed-effects regression analyses were conducted to assess changes over time in these constructs. Qualitative analyses were integrated to help provide validation and understanding.

RESULTS

Innovation-values fit and organizational readiness for change were found to be high and relatively stable. However, significant curvilinear change over time was found for implementation climate. Based on the qualitative data, implementation climate declined toward the end of implementation because of decreased engagement from clinic champions and differences in priorities between research and clinic staff.

CONCLUSIONS

The Positive Health Check intervention was found to fit within HIV primary care service settings, but there were some logistical challenges that needed to be addressed. Additionally, even within the context of an effectiveness trial, significant and nonlinear change in implementation climate should be expected over time.

摘要

背景

Positive Health Check 是一种基于证据的视频医生干预措施,旨在提高接受临床护理的艾滋病毒感染者的药物依从性、治疗保留率和病毒载量抑制率。

地点

美国的四个艾滋病毒初级保健诊所。

方法

作为 1 型混合试验的一部分,采用混合方法学在 23 个月的时间内纵向评估以下 3 个关键实施结构:创新价值契合度(即员工认为创新使用将在多大程度上促进其价值观的实现)、组织变革准备度(即组织成员在心理和行为上准备实施组织变革的程度)和实施氛围(即实施在多大程度上被期望、支持和奖励)。进行定量混合效应回归分析,以评估这些结构随时间的变化。整合定性分析以帮助提供验证和理解。

结果

发现创新价值契合度和组织变革准备度较高且相对稳定。然而,实施氛围随时间呈显著曲线变化。根据定性数据,由于诊所拥护者的参与度下降以及研究和诊所工作人员之间的优先事项存在差异,实施氛围在实施结束时下降。

结论

Positive Health Check 干预措施被发现适合艾滋病毒初级保健服务环境,但存在一些需要解决的后勤挑战。此外,即使在有效性试验的背景下,实施氛围也会随着时间的推移而发生重大且非线性的变化。

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