Department of Physiotherapy, Korle Bu Teaching Hospital, Accra, Ghana.
Department of Epidemiology, School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana.
PLoS One. 2022 May 18;17(5):e0268711. doi: 10.1371/journal.pone.0268711. eCollection 2022.
Coronavirus Disease (COVID-19) vaccine acceptance, and hesitancy amongst Health Care Workers (HCWs) on the African continent have been examined through observational studies. However, there are currently no comprehensive reviews among these cadre of population in Africa. Hence, we aimed to review the acceptance rate and possible reasons for COVID-19 vaccine non-acceptance/hesitancy amongst HCWs in Africa.
We searched Medline/PubMed, Google Scholar, and Africa Journal Online from January, 2020 to September, 2021. The Newcastle-Ottawa Quality Assessment tool adapted for cross-sectional studies was used to assess the quality of the retrieved studies. DerSimonian and Laird random-effects model was used to pool the COVID-19 vaccine acceptance rate. Sub-group and sensitivity analyses were performed. Reasons for COVID-19 vaccine hesitancy were also systematically analyzed.
Twenty-one (21) studies were found to be eligible for review out of the 513 initial records. The estimated pooled COVID-19 vaccine acceptance rate was 46% [95% CI: 37%-54%]. The pooled estimated COVID-19 vaccine acceptance rate was 37% [95% CI: 27%-47%] in North Africa, 28% [95% CI: 20%-36%] in Central Africa, 48% [CI: 38%-58%] in West Africa, 49% [95% CI: 30%-69%] in East Africa, and 90% [CI: 85%-96%] in Southern Africa. The estimated pooled vaccine acceptance was 48% [95% CI:38%-57%] for healthcare workers, and 34% [95% CI:29%-39%] for the healthcare students. Major drivers and reasons were the side effects of the vaccine, vaccine's safety, efficacy and effectiveness, short duration of the clinical trials, COVID-19 infections, limited information, and social trust.
The data revealed generally low acceptance of the vaccine amongst HCWs across Africa. The side effects of the vaccine, vaccine's safety, efficacy and effectiveness, short duration of the clinical trials, COVID-19 infections, limited information, and social trust were the major reasons for COVID-19 hesitancy in Africa. The misconceptions and barriers to COVID-19 vaccine acceptance amongst HCWs must be addressed as soon as possible in the continent to boost COVID-19 vaccination rates in Africa.
在非洲大陆，针对冠状病毒疾病（COVID-19）疫苗的接受程度以及医疗保健工作者（HCWs）的犹豫态度，已经通过观察性研究进行了检查。然而，目前在非洲这一人群中还没有全面的综述。因此，我们旨在回顾非洲 HCWs 对 COVID-19 疫苗的接受率以及对其不接受/犹豫的可能原因。
我们检索了 Medline/PubMed、Google Scholar 和 Africa Journal Online 从 2020 年 1 月到 2021 年 9 月的内容。使用适用于横断面研究的纽卡斯尔-渥太华质量评估工具来评估检索到的研究的质量。采用 DerSimonian 和 Laird 随机效应模型来汇总 COVID-19 疫苗接种率。进行了亚组和敏感性分析。还系统地分析了 COVID-19 疫苗犹豫的原因。
从最初的 513 条记录中，发现有 21 项研究符合审查条件。估计的 COVID-19 疫苗接种率为 46%[95%CI：37%-54%]。北非的 COVID-19 疫苗接种率估计为 37%[95%CI：27%-47%]，中非为 28%[95%CI：20%-36%]，西非为 48%[CI：38%-58%]，东非为 49%[95%CI：30%-69%]，南部非洲为 90%[CI：85%-96%]。医护人员疫苗接种的估计接种率为 48%[95%CI：38%-57%]，医学生为 34%[95%CI：29%-39%]。主要驱动力和原因是疫苗的副作用、疫苗的安全性、有效性和效果、临床试验持续时间短、COVID-19 感染、信息有限和社会信任。
数据显示，非洲各地的 HCWs 对疫苗的总体接受程度较低。疫苗的副作用、疫苗的安全性、有效性和效果、临床试验持续时间短、COVID-19 感染、信息有限和社会信任是非洲 COVID-19 犹豫不决的主要原因。必须尽快解决 HCWs 对 COVID-19 疫苗的误解和接受障碍，以提高非洲的 COVID-19 疫苗接种率。
Zotero 插件
