Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India.
Department of Preventive and Social Medicine, Rajendra Institute of Medical Sciences, Ranchi, India.
Pathog Glob Health. 2024 Mar;118(2):182-195. doi: 10.1080/20477724.2023.2285184. Epub 2023 Nov 20.
Vaccination against COVID-19 is vital for achieving herd immunity, and the Government of India has adopted several strategies to achieve coverage. Vaccine hesitancy was identified as a potential obstacle in combating COVID-19. This study aimed to review the COVID-19 vaccine acceptance and hesitancy, and factors associated with vaccine hesitancy based on studies conducted in Indian populations. The data sources (PubMed, Scopus, and Google Scholar) were searched by following PRISMA guidelines, and the search was done in September 2022. We performed a meta-analysis through a random effect model to estimate pooled hesitancy rate with 95% confidence intervals (CI). A total of 3,339 records were searched, of which 46 studies were found to be eligible for inclusion in the review. The included studies covered 65,551 respondents, 55% were female. Studies reported COVID-19 vaccine acceptance rate of 65.7% in January-February 2021, which increased to 92.8% in May-August 2021. Likewise, the rate of vaccine hesitancy in December 2020 was 37%, dropping to 12.1% through November 2021. The estimated pooled COVID-19 vaccine hesitancy was 31% [95% CI: 27% - 36%, I = 99.3%]. Most studies highlighted that fear of the vaccine's side effects, efficacy, and safety were major barriers to vaccine acceptance. However, as the review indicates, it is important to consider and address all factors contributing to vaccine hesitancy.
接种 COVID-19 疫苗对于实现群体免疫至关重要，印度政府采取了多种策略来实现疫苗接种覆盖。疫苗犹豫被认为是抗击 COVID-19 的潜在障碍。本研究旨在根据在印度人群中进行的研究，回顾 COVID-19 疫苗的接受和犹豫情况，以及与疫苗犹豫相关的因素。通过遵循 PRISMA 指南，在 PubMed、Scopus 和 Google Scholar 上搜索数据来源，并于 2022 年 9 月进行了搜索。我们通过随机效应模型进行了荟萃分析，以估计合并犹豫率及其 95%置信区间 (CI)。共搜索了 3339 条记录，其中有 46 项研究被认为符合纳入审查的条件。纳入的研究涵盖了 65551 名受访者，其中 55%为女性。研究报告称，2021 年 1 月至 2 月 COVID-19 疫苗的接受率为 65.7%，2021 年 5 月至 8 月上升至 92.8%。同样，2020 年 12 月疫苗犹豫率为 37%，到 2021 年 11 月降至 12.1%。估计的合并 COVID-19 疫苗犹豫率为 31%[95%CI：27%-36%，I=99.3%]。大多数研究强调，对疫苗副作用、疗效和安全性的担忧是疫苗接种接受的主要障碍。然而，正如综述所表明的，重要的是要考虑并解决导致疫苗犹豫的所有因素。
