van Baardwijk C, Roach M R
J Biomech. 1987;20(1):67-73. doi: 10.1016/0021-9290(87)90268-5.
Factors were examined which altered the propagation of aortic dissections in canine aortas. Thoracic aortas were removed from sacrificed dogs from the distal end of the arch to the diaphragm. An intimal tear was created at the proximal end of the aorta. The dissection was propagated using a pulsatile pressure system with no flow. The aorta was perfused with a dilute black paint solution, which allowed both video monitoring of the extension of the dissection and measurement of the dissection rate. The dependence of the dissection rate on the variables peak pressure, (dP/dt)max and intimal tear depth was examined. The dissection rate was found to be dependent on (dP/dt)max (p less than 0.005) and the intimal tear depth, expressed as a percentage of wall thickness (p less than 0.01), but not on the peak pressure or intimal tear length. The equation relating the significant variables was log (dissection rate) = (-0.034) X % tear depth +(1.89 +/- 0.56) X (dP/dt)max -(4.3 +/- 1.8); r = 78. Thus a higher (dP/dt)max was associated with a more rapid dissection rate and a deeper intimal tear was associated with a slower dissection rate.
研究了影响犬主动脉夹层扩展的因素。从处死的犬只身上取下胸主动脉，范围从主动脉弓远端至膈肌。在主动脉近端制造一个内膜撕裂口。使用无血流的脉动压力系统使夹层扩展。用稀释的黑色涂料溶液灌注主动脉，这既能通过视频监测夹层的扩展情况，又能测量夹层扩展速率。研究了夹层扩展速率与变量峰值压力、最大压力变化率（dP/dt）max以及内膜撕裂深度的相关性。结果发现夹层扩展速率取决于最大压力变化率（p<0.005）以及以内膜厚度百分比表示的内膜撕裂深度（p<0.01），但与峰值压力或内膜撕裂长度无关。相关显著变量的方程为log（夹层扩展速率）=（-0.034）×撕裂深度百分比 +（1.89±0.56）×最大压力变化率 -（4.3±1.8）；r = 78。因此，更高的最大压力变化率与更快的夹层扩展速率相关，而更深的内膜撕裂与更慢的夹层扩展速率相关。
