Keller J C, Young F A, Natiella J R
J Biomed Mater Res. 1987 Mar;21(3):305-19. doi: 10.1002/jbm.820210304.
Histomorphometric analyses were used to quantitatively determine the patterns of bony ingrowth which resulted from the placement of porous-surfaced dental implants into the mandibles of Rhesus monkeys for up to 74 months utilizing a two-stage approach. Quantitative histopathologic evaluations were made using ground section microscopy. Implant stability resulting from bone remodelling and ingrowth occurred to varying degrees with all implants. Bone ingrowth occurred from medullary trabeculae and contact with the adjacent cortical plates. Quantitative histomorphometric analyses revealed that in only one case was the bone ingrowth into the available internal pores less than 45%. Minimal fibrous connective tissue ingrowth was observed in the implant crypts and was not thought to be due to micro-motion. The observed bone remodelling indicated a favorable prognosis for long-term implant performance.
组织形态计量学分析用于定量确定骨长入模式，该模式是通过两阶段方法将多孔表面牙种植体植入恒河猴下颌骨长达74个月而产生的。使用磨片显微镜进行定量组织病理学评估。所有种植体都不同程度地发生了由骨重塑和长入导致的种植体稳定性。骨长入发生于髓质小梁并与相邻皮质板接触。组织形态计量学定量分析显示，仅在1例中，骨长入可用内部孔隙的比例小于45%。在种植体窝内观察到最小限度的纤维结缔组织长入，并且认为这不是由微动引起的。观察到的骨重塑表明种植体长期性能的预后良好。
