Ahmed Asmaa Bashir, Tahir Hafiz Muhammad, Yousaf Muhammad Shahbaz, Munir Fareeha, Ali Shaukat
Department of Zoology, Government College University, Lahore, Pakistan.
Department of Physiology, University of Veterinary and Animal Sciences, Lahore, Pakistan.
J Burn Care Res. 2023 Jan 5;44(1):58-64. doi: 10.1093/jbcr/irac069.
Burns wounds are one of the most health-threatening problems worldwide. Sericin is a natural protein synthesized by the silkworm Bombyx mori L. It is a natural biomaterial that helps in the management of wounds by promoting the proliferation of fibroblasts and keratinocytes. Jasminum grandiflorum L leaves contain high mucilage content and have been used to cure various dermal wounds in ancient times. The present study was aimed to investigate the individual and synergetic effect of sericin and J. grandiflorum leaves extract on burn injury in mice. Ten-week-old mice weighing 22 g ± 5 g were randomly divided into eight groups, each group containing 10 mice. Burn injury in mice was induced by using a hot metal rod. Wounds were evaluated morphologically and histologically. In comparison with controls, 4% sericin + jasmine (S + J) expressively improved wound contraction area. Restoration of the epidermis was also faster in S + J 4% group (P ≤ .01) than in other groups. Histopathological analysis also verified the efficacy of the 4% S + J cream. It is concluded that a mixture of sericin and jasmine leaves effectively improved the healing process of skin burns.
烧伤创面是全球最具健康威胁的问题之一。丝胶蛋白是家蚕合成的一种天然蛋白质。它是一种天然生物材料，通过促进成纤维细胞和角质形成细胞的增殖来帮助伤口愈合。大花茉莉叶含有高黏液质，在古代已被用于治疗各种皮肤创伤。本研究旨在探讨丝胶蛋白和大花茉莉叶提取物对小鼠烧伤损伤的单独及协同作用。将体重为22 g±5 g的10周龄小鼠随机分为8组，每组10只。使用热金属棒诱导小鼠烧伤损伤。对伤口进行形态学和组织学评估。与对照组相比，4%丝胶蛋白+茉莉（S+J）显著改善了伤口收缩面积。4% S+J组的表皮恢复也比其他组更快（P≤0.01）。组织病理学分析也证实了4% S+J乳膏的疗效。得出结论，丝胶蛋白和茉莉叶的混合物有效改善了皮肤烧伤的愈合过程。
