Nottingham Digestive Diseases Centre, Nottingham, UK, NIHR Nottingham Biomedical Research Centre, Nottingham, UK and Nottingham University Hospitals NHS Trust, Nottingham, UK.
University of Nottingham, Nottingham, UK, NIHR Nottingham Biomedical Research Centre, Nottingham, UK, Nottingham University Hospitals NHS Trust, Nottingham, UK and East Midlands Academic Health Science Network, Nottingham, UK.
Clin Med (Lond). 2022 May;22(3):192-196. doi: 10.7861/clinmed.2021-0603.
To determine the maximal response of the temperature and inflammatory response to SARS-CoV-2 infection and how these are modified by age.
Participants were patients admitted to hospital with SARS-CoV-2 infection. For each participant, the maximal temperature and serum C-reactive protein (CRP) were identified and stratified by age. In a secondary analysis, these were compared in patients treated before and after dexamethasone.
Mean maximal temperature varied by age (p<0.001; ANOVA) with the highest mean maximal temperature of 37.3°C observed in patients aged 30-49 years and decreasing maximal mean temperatures in the older age groups, with the lowest measure of 36.8°C observed in individuals aged 90-99 years. The mean maximal serum CRP also varied across age groups (p<0.001; ANOVA) and increased with age across all age categories from 34.5 mg/dL (95% confidence interval (CI) 22.0-47.0) for individuals aged 20-29 years to 77.6 mg/dL (95% CI 72.0-83.2) in those aged 80-89 years. After dexamethasone became standard treatment for COVID-19 pneumonia, mean maximal CRP decreased by 17 mg/dL (95% CI -22 to -11).
Age modifies both maximal temperature and systemic inflammatory response in patients with SARS-CoV-2 infection.
确定体温和炎症反应对 SARS-CoV-2 感染的最大反应以及年龄如何对此产生影响。
研究对象为因 SARS-CoV-2 感染而住院的患者。对每位患者的最高体温和血清 C 反应蛋白（CRP）进行了确定，并按年龄进行了分层。在二次分析中，比较了地塞米松治疗前后患者的这些指标。
平均最高体温因年龄而异（p<0.001；方差分析），30-49 岁患者的平均最高体温最高，为 37.3°C，年龄较大的患者体温逐渐降低，90-99 岁患者的平均最高体温最低，为 36.8°C。平均最高血清 CRP 也随年龄组而变化（p<0.001；方差分析），所有年龄组的 CRP 均随年龄的增加而增加，从 20-29 岁患者的 34.5mg/dL（95%置信区间[CI] 22.0-47.0）到 80-89 岁患者的 77.6mg/dL（95% CI 72.0-83.2）。地塞米松成为 COVID-19 肺炎的标准治疗方法后，平均最高 CRP 下降了 17mg/dL（95% CI -22 至-11）。
年龄会改变 SARS-CoV-2 感染患者的最高体温和全身炎症反应。
