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玉米醇溶蛋白水解物糖基化作为叶黄素递送纳米载体的研究：制备与稳定性

Glycosylation of Zein Hydrolysate as a Nanocarrier for Lutein Delivery: Preparation and Stability.

作者信息

Han He, Jiao Yan, Chang Ying, Cheng Yue, Shi Lei

机构信息

College of Food and Bioengineering, Qiqihar University, Qiqihar, China.

出版信息

Front Pharmacol. 2022 May 2;13:905059. doi: 10.3389/fphar.2022.905059. eCollection 2022.

DOI:10.3389/fphar.2022.905059
PMID:35586048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9108384/
Abstract

Lutein is a functional carotenoid that has a wide range of physiological benefits in humans. However, it easily degrades and becomes inactivated during storage and processing, resulting in low bioavailability. The development of new nanocarriers can effectively improve the stability and biological activity of lutein. In this study, zein hydrolysate (ZH) carriers were glycosylated with glucosamine (GLU) under the action of transglutaminase, and lutein-loaded glycosylated ZH nanoparticles (GZH-LUT) were constructed by liquid-liquid dispersion. The results showed that the GZH-LUT particles had a narrow size distribution in the range of 200-300 nm and a decreased zeta potential and polydispersity index. In particular, GZH trapped lutein more efficiently than ZH. In addition, GZH-LUT had better physical and chemical properties, including better water solubility, oxidative stability, and environmental stability than free lutein and ZH-LUT. These results indicate that glycosylated zein hydrolysate has the potential to be used as a novel protein-based nanocarrier to enhance the solubility and stability of lutein, which can further improve its bioavailability.

摘要

叶黄素是一种功能性类胡萝卜素，对人体具有广泛的生理益处。然而，它在储存和加工过程中容易降解并失活，导致生物利用度较低。新型纳米载体的开发可以有效提高叶黄素的稳定性和生物活性。在本研究中，玉米醇溶蛋白水解物（ZH）载体在转谷氨酰胺酶的作用下与氨基葡萄糖（GLU）进行糖基化反应，并通过液-液分散法构建了负载叶黄素的糖基化ZH纳米颗粒（GZH-LUT）。结果表明，GZH-LUT颗粒的粒径分布较窄，在200-300nm范围内，且zeta电位和多分散指数降低。特别是，GZH比ZH更有效地捕获叶黄素。此外，GZH-LUT具有更好的物理和化学性质，包括比游离叶黄素和ZH-LUT更好的水溶性、氧化稳定性和环境稳定性。这些结果表明，糖基化玉米醇溶蛋白水解物有潜力作为一种新型的基于蛋白质的纳米载体，以提高叶黄素的溶解度和稳定性，从而进一步提高其生物利用度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/ff8a30659e09/fphar-13-905059-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/a53f729e4a81/fphar-13-905059-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/de5d145b9fac/fphar-13-905059-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/7872174bbffa/fphar-13-905059-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/dda35327946f/fphar-13-905059-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/e91d7244bed3/fphar-13-905059-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/3ee76c19dcc9/fphar-13-905059-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/28b66f5cc79d/fphar-13-905059-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/3534721e6a04/fphar-13-905059-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/070524bb3d88/fphar-13-905059-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/ff8a30659e09/fphar-13-905059-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/a53f729e4a81/fphar-13-905059-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/de5d145b9fac/fphar-13-905059-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/7872174bbffa/fphar-13-905059-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/dda35327946f/fphar-13-905059-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/e91d7244bed3/fphar-13-905059-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/3ee76c19dcc9/fphar-13-905059-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/28b66f5cc79d/fphar-13-905059-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/3534721e6a04/fphar-13-905059-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/070524bb3d88/fphar-13-905059-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d17/9108384/ff8a30659e09/fphar-13-905059-g010.jpg

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