Yang Yuxian, Li Shuting, Xu Yuechao, Ke Jing, Zhao Dong
Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital, Capital Medical University, Beijing, People's Republic of China.
Diabetes Metab Syndr Obes. 2022 May 11;15:1505-1515. doi: 10.2147/DMSO.S350579. eCollection 2022.
Obesity is an important risk factor for nonalcoholic fatty liver disease (NAFLD). Perirenal fat and paranephric fat were seldom studied in NAFLD. We aimed to explore the relationship between perirenal fat thickness (PrFT) and paranephric fat thickness (PnFT) and NAFLD in patients with type 2 diabetes mellitus (T2DM).
A total of 493 diabetic patients including 231 NAFLD patients were enrolled in our study from September 2019 to December 2020. Patients with NAFLD were categorized into three subgroups according to the severity and fibrosis risk of NAFLD. Anthropometric indices and clinical characteristics were collected from clinical records. PrFT and PnFT were measured via ultrasound. Multivariate logistic regression analysis was used to assess the association between PrFT, PnFT and presence, severity and advanced fibrosis risk of NAFLD.
Compared with non-NAFLD patients, those with NAFLD had significantly higher PrFT and PnFT. The PrFT and PnFT were independently associated with presence of NAFLD and the PrFT was independently associated with the advanced fibrosis risk of NAFLD after adjusting confounding factors.
The PrFT was independently associated with the presence and advanced fibrosis risk of NAFLD in patients with T2DM.
肥胖是非酒精性脂肪性肝病（NAFLD）的重要危险因素。肾周脂肪和肾旁脂肪在NAFLD中的研究较少。我们旨在探讨2型糖尿病（T2DM）患者肾周脂肪厚度（PrFT）和肾旁脂肪厚度（PnFT）与NAFLD之间的关系。
2019年9月至2020年12月，共有493例糖尿病患者纳入本研究，其中231例为NAFLD患者。根据NAFLD的严重程度和纤维化风险，将NAFLD患者分为三个亚组。从临床记录中收集人体测量指标和临床特征。通过超声测量PrFT和PnFT。采用多因素logistic回归分析评估PrFT、PnFT与NAFLD的存在、严重程度及晚期纤维化风险之间的关联。
与非NAFLD患者相比，NAFLD患者的PrFT和PnFT显著更高。在调整混杂因素后，PrFT和PnFT与NAFLD的存在独立相关，且PrFT与NAFLD的晚期纤维化风险独立相关。
PrFT与T2DM患者NAFLD的存在及晚期纤维化风险独立相关。
