• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

甘草次酸内酯，一种来自甘草的香豆素化合物，通过抑制 TRIF 依赖性 IRF-3 信号和 NF-κB 通路发挥抗炎活性。

Anti-Inflammatory Activity of Glabralactone, a Coumarin Compound from , via Suppression of TRIF-Dependent IRF-3 Signaling and NF-B Pathways.

机构信息

College of Pharmacy, Natural Products Research Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea.

出版信息

Mediators Inflamm. 2022 May 9;2022:5985255. doi: 10.1155/2022/5985255. eCollection 2022.

DOI:10.1155/2022/5985255
PMID:35586367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9110254/
Abstract

The dried root of () has been widely used in Chinese traditional medicine for various diseases such as inflammation, osteoarthritis, infections, mild anemia, fatigue, and high blood pressure. Searching for the secondary metabolites of has been mainly conducted. However, the bioactivity of coumarins in the plant remains unexplored. Therefore, this study was designed to evaluate the anti-inflammatory activity of glabralactone, a coumarin compound from , using and models, and to elucidate the underlying molecular mechanisms of action. Glabralactone effectively inhibited nitric oxide production in lipopolysaccharide- (LPS-) stimulated RAW264.7 macrophage cells. The downregulation of LPS-induced mRNA and protein expression of iNOS, TNF-, IL-1, and miR-155 was found by glabralactone. The activation of NF-B and TRIF-dependent IRF-3 pathway was also effectively suppressed by glabralactone in LPS-stimulated macrophages. Glabralactone (5 and 10 mg/kg) exhibited an anti-inflammatory activity with the reduction of paw edema volume in carrageenan-induced rat model, and the expressions of iNOS and IL-1 proteins were suppressed by glabralactone in the paw soft tissues of the animal model. Taken together, glabralactone exhibited an anti-inflammatory activity in and models. These findings reveal that glabralactone might be one of the potential components for the anti-inflammatory activity of and may be prioritized in the development of a chemotherapeutic agent for the treatment of inflammatory diseases.

摘要

（）的干根在中医中被广泛用于治疗各种疾病，如炎症、骨关节炎、感染、轻度贫血、疲劳和高血压。主要对其进行了次生代谢产物的研究。然而，该植物中香豆素的生物活性仍未得到探索。因此，本研究旨在评估来自的香豆素化合物 glabralactone 的抗炎活性，采用 和 模型，并阐明其作用的潜在分子机制。Glabralactone 有效抑制脂多糖-（LPS-）刺激的 RAW264.7 巨噬细胞中一氧化氮的产生。发现 glabralactone 下调了 LPS 诱导的 iNOS、TNF-、IL-1 和 miR-155 的 mRNA 和蛋白表达。LPS 刺激的巨噬细胞中 NF-B 和 TRIF 依赖性 IRF-3 途径的激活也被 glabralactone 有效抑制。Glabralactone（5 和 10mg/kg）在角叉菜胶诱导的大鼠模型中表现出抗炎活性，减少了爪肿胀体积，并且 glabralactone 抑制了动物模型爪软组织中 iNOS 和 IL-1 蛋白的表达。总之，glabralactone 在 和 模型中表现出抗炎活性。这些发现表明 glabralactone 可能是 的抗炎活性的潜在成分之一，并可能在开发用于治疗炎症性疾病的化学治疗剂时被优先考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/8e9f7190193f/MI2022-5985255.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/c6034d347342/MI2022-5985255.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/230814efbfeb/MI2022-5985255.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/fd2a10b295c0/MI2022-5985255.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/45bf9f68329a/MI2022-5985255.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/21bf990e8eb8/MI2022-5985255.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/8e9f7190193f/MI2022-5985255.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/c6034d347342/MI2022-5985255.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/230814efbfeb/MI2022-5985255.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/fd2a10b295c0/MI2022-5985255.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/45bf9f68329a/MI2022-5985255.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/21bf990e8eb8/MI2022-5985255.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21b3/9110254/8e9f7190193f/MI2022-5985255.006.jpg

相似文献

1
Anti-Inflammatory Activity of Glabralactone, a Coumarin Compound from , via Suppression of TRIF-Dependent IRF-3 Signaling and NF-B Pathways.甘草次酸内酯，一种来自甘草的香豆素化合物，通过抑制 TRIF 依赖性 IRF-3 信号和 NF-κB 通路发挥抗炎活性。
Mediators Inflamm. 2022 May 9;2022:5985255. doi: 10.1155/2022/5985255. eCollection 2022.
2
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.白头翁素，一种来自菊科植物的半日花烷二聚体，通过下调 NF-κB 信号通路和促炎细胞因子的产生来抑制炎症反应。
J Nat Prod. 2014 Apr 25;77(4):917-24. doi: 10.1021/np4009877. Epub 2014 Apr 1.
3
Mechanism of anti-inflammatory activity of umbelliferone 6-carboxylic acid isolated from Angelica decursiva.当归中分离得到的伞形酮 6-羧酸的抗炎活性机制。
J Ethnopharmacol. 2012 Oct 31;144(1):175-81. doi: 10.1016/j.jep.2012.08.048. Epub 2012 Sep 8.
4
Pinosylvin suppresses LPS-stimulated inducible nitric oxide synthase expression via the MyD88-independent, but TRIF-dependent downregulation of IRF-3 signaling pathway in mouse macrophage cells.松二氢茚醇通过MyD88非依赖但TRIF依赖的IRF-3信号通路下调，抑制小鼠巨噬细胞中脂多糖刺激的诱导型一氧化氮合酶表达。
Cell Physiol Biochem. 2011;27(3-4):353-62. doi: 10.1159/000327961. Epub 2011 Apr 1.
5
Ethyl acetate fraction from Nymphaea hybrida Peck modulates inflammatory responses in LPS-stimulated RAW 264.7 cells and acute inflammation murine models.芡荷叶乙酸乙酯部位对脂多糖诱导的 RAW264.7 细胞炎症反应和急性炎症模型的调节作用。
J Ethnopharmacol. 2021 Apr 6;269:113698. doi: 10.1016/j.jep.2020.113698. Epub 2020 Dec 15.
6
Anti-Inflammatory Effects of (Oliv.) Diels Water Extract on RAW 264.7 Induced with Lipopolysaccharide.（Oliv.）Diels 水提取物对脂多糖诱导的 RAW 264.7 的抗炎作用。
Nutrients. 2018 May 21;10(5):647. doi: 10.3390/nu10050647.
7
Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo.云芝中的茵陈色酮通过体外和体内抑制 MMP-9、NF-κB 和 MAPK 的激活发挥抗炎作用。
PLoS One. 2012;7(5):e35922. doi: 10.1371/journal.pone.0035922. Epub 2012 May 8.
8
Anti-inflammatory potential of L. leaf extract in LPS-stimulated RAW264.7 cells and in a rat model of carrageenan-induced inflammation.L. 叶提取物在 LPS 刺激的 RAW264.7 细胞和角叉菜胶诱导的炎症大鼠模型中的抗炎潜力。
Arch Physiol Biochem. 2020 Feb;126(1):74-81. doi: 10.1080/13813455.2018.1493607. Epub 2018 Oct 15.
9
Arsenic trioxide prevents nitric oxide production in lipopolysaccharide -stimulated RAW 264.7 by inhibiting a TRIF-dependent pathway.三氧化二砷通过抑制 TRIF 依赖性途径来防止脂多糖刺激的 RAW 264.7 细胞中一氧化氮的产生。
Cancer Sci. 2013 Feb;104(2):165-70. doi: 10.1111/cas.12053. Epub 2012 Dec 13.
10
Nodakenin suppresses lipopolysaccharide-induced inflammatory responses in macrophage cells by inhibiting tumor necrosis factor receptor-associated factor 6 and nuclear factor-κB pathways and protects mice from lethal endotoxin shock.野鸦椿苦丁素通过抑制肿瘤坏死因子受体相关因子 6 和核因子-κB 通路抑制巨噬细胞中的脂多糖诱导的炎症反应，并保护小鼠免受致死性内毒素休克。
J Pharmacol Exp Ther. 2012 Sep;342(3):654-64. doi: 10.1124/jpet.112.194613. Epub 2012 May 25.

引用本文的文献

1
Coumarin: A natural solution for alleviating inflammatory disorders.香豆素：缓解炎症性疾病的天然解决方案。
Curr Res Pharmacol Drug Discov. 2024 Sep 25;7:100202. doi: 10.1016/j.crphar.2024.100202. eCollection 2024.
2
Exploring the mechanism by which improves haematopoietic function in aplastic anaemia.探讨 改善再生障碍性贫血造血功能的机制。
Aging (Albany NY). 2024 Jun 26;16(15):11535-11552. doi: 10.18632/aging.205971.
3
Integrated Network Pharmacology and Experimental Validation Approach to Investigate the Mechanisms of Radix Rehmanniae Praeparata - Angelica Sinensis - Radix Achyranthis Bidentatae in Treating Knee Osteoarthritis.

本文引用的文献

1
Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity.Toll样受体信号传导及其在细胞介导免疫中的作用。
Front Immunol. 2022 Mar 3;13:812774. doi: 10.3389/fimmu.2022.812774. eCollection 2022.
2
Macrophages: The Good, the Bad, and the Gluttony.巨噬细胞：亦善亦恶亦饕餮。
Front Immunol. 2021 Aug 12;12:708186. doi: 10.3389/fimmu.2021.708186. eCollection 2021.
3
NF-κB: At the Borders of Autoimmunity and Inflammation.NF-κB：自身免疫和炎症的交界处。
基于整合网络药理学与实验验证探究地黄-当归-牛膝治疗膝骨关节炎作用机制的方法。
Drug Des Devel Ther. 2024 May 15;18:1583-1602. doi: 10.2147/DDDT.S455006. eCollection 2024.
4
cGAS-STING pathway in pathogenesis and treatment of osteoarthritis and rheumatoid arthritis.cGAS-STING 通路在骨关节炎和类风湿关节炎发病机制和治疗中的作用。
Front Immunol. 2024 May 3;15:1384372. doi: 10.3389/fimmu.2024.1384372. eCollection 2024.
5
The Dynamic Accumulation Rules of Chemical Components during the Medicine Formation Period of and Chemometric Classifying Analysis for Different Bolting Times Using ATR-FTIR.基于衰减全反射傅里叶变换红外光谱法的不同打顶时期烟草化学成分形成期动态积累规律及化学计量分类分析
Molecules. 2023 Oct 27;28(21):7292. doi: 10.3390/molecules28217292.
6
Anti-fatigue effect of traditional Chinese medicines: A review.中药的抗疲劳作用：综述
Saudi Pharm J. 2023 Apr;31(4):597-604. doi: 10.1016/j.jsps.2023.02.013. Epub 2023 Mar 9.
7
Synthesis and Vasorelaxant Activity of Nitrate-Coumarin Derivatives.硝酮香豆素衍生物的合成及血管舒张活性研究
ChemMedChem. 2022 Nov 4;17(21):e202200476. doi: 10.1002/cmdc.202200476. Epub 2022 Oct 13.
Front Immunol. 2021 Aug 9;12:716469. doi: 10.3389/fimmu.2021.716469. eCollection 2021.
4
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019.天然产物：1981 年 1 月至 2019 年 9 月近四十年来的新药来源
J Nat Prod. 2020 Mar 27;83(3):770-803. doi: 10.1021/acs.jnatprod.9b01285. Epub 2020 Mar 12.
5
Signalling, sorting and scaffolding adaptors for Toll-like receptors.Toll 样受体的信号转导、分拣和支架衔接蛋白
J Cell Sci. 2019 Dec 30;133(5):jcs239194. doi: 10.1242/jcs.239194.
6
In Vitro and In Vivo Anti-Allergic and Anti-Inflammatory Effects of eBV, a Newly Developed Derivative of Bee Venom, through Modulation of IRF3 Signaling Pathway in a Carrageenan-Induced Edema Model.新型蜂毒衍生物eBV在角叉菜胶诱导的水肿模型中通过调节IRF3信号通路发挥的体外和体内抗过敏及抗炎作用
PLoS One. 2016 Dec 8;11(12):e0168120. doi: 10.1371/journal.pone.0168120. eCollection 2016.
7
Inflammation: maladies, models, mechanisms and molecules.炎症：疾病、模型、机制与分子
Br J Pharmacol. 2016 Feb;173(4):631-4. doi: 10.1111/bph.13389.
8
Suppression of inducible nitric oxide synthase expression by nyasol and broussonin A, two phenolic compounds from Anemarrhena asphodeloides, through NF-κB transcriptional regulation in vitro and in vivo.尼索醇和梓醇 A 抑制诱导型一氧化氮合酶表达的体外和体内研究：两种来自知母的酚类化合物通过 NF-κB 转录调控。
Chem Biodivers. 2014 May;11(5):749-59. doi: 10.1002/cbdv.201400003.
9
Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.白头翁素，一种来自菊科植物的半日花烷二聚体，通过下调 NF-κB 信号通路和促炎细胞因子的产生来抑制炎症反应。
J Nat Prod. 2014 Apr 25;77(4):917-24. doi: 10.1021/np4009877. Epub 2014 Apr 1.
10
Anti-inflammatory therapy in chronic disease: challenges and opportunities.慢性病的抗炎治疗：挑战与机遇。
Science. 2013 Jan 11;339(6116):166-72. doi: 10.1126/science.1230720.