Chen Linfa, Wang Ying, Wang Yajun, Huang Shaoting, Wu Zhaochun, He Jiawen, Zhong Wangtao, Zhao Bin, Ma Guoda, Li You
Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, People's Republic of China.
Department of Neurology, Huizhou Third People's Hospital, Guangzhou Medical University, Huizhou, Guangdong, 516002, People's Republic of China.
Pharmgenomics Pers Med. 2022 May 11;15:477-485. doi: 10.2147/PGPM.S364648. eCollection 2022.
Emerging evidences suggest that the angiotensin receptor type 1 (AT1R) contributes heavily to the pathogenesis of atherosclerotic cerebral infarction (ACI). Herein, we examined a potential link between AT1R gene polymorphisms and ACI risk among a Southern Han Chinese population.
The rs3772616, rs275645, and rs377262 AT1R polymorphisms were genotyped in 689 ACI patients and 712 healthy controls, using the iMLDR-TM assay.
The genotypic and allelic frequencies of AT1R rs3772616 differed tremendously between ACI patients and healthy controls, and the rs3772616 T allele is a risk allele for ACI. However, the rs275645 and rs377262 allelic and genotypic frequency distributions were comparable between ACI patients and controls. In addition, the G-T-T haplotype was linked to an enhanced risk of ACI. We, next, classified our study subjects based on environmental factors and revealed that the rs3772616 T allele was strongly associated with an elevated ACI risk in males, hypertensive individuals, and those over 65 years old. In addition, we observed a marked link between the rs3772616 T allele and enhanced AT1R levels.
Based on our research, there is a strong correlation between the AT1R rs3772616 polymorphism and enhanced ACI risk. Hence, the AT1R rs3772616 polymorphism can serve as a potential therapeutic target and bioindicator for ACI development.
新出现的证据表明，1型血管紧张素受体（AT1R）在动脉粥样硬化性脑梗死（ACI）的发病机制中起重要作用。在此，我们研究了中国南方汉族人群中AT1R基因多态性与ACI风险之间的潜在联系。
采用iMLDR-TM检测法对689例ACI患者和712例健康对照者的rs3772616、rs275645和rs377262 AT1R多态性进行基因分型。
ACI患者和健康对照者之间AT1R rs3772616的基因型和等位基因频率差异极大，rs3772616 T等位基因是ACI的风险等位基因。然而，ACI患者和对照组之间rs275645和rs377262的等位基因和基因型频率分布相当。此外，G-T-T单倍型与ACI风险增加有关。接下来，我们根据环境因素对研究对象进行分类，发现rs3772616 T等位基因与男性、高血压患者和65岁以上人群的ACI风险升高密切相关。此外，我们观察到rs3772616 T等位基因与AT1R水平升高之间存在明显联系。
基于我们的研究，AT1R rs3772616多态性与ACI风险增加之间存在很强的相关性。因此，AT1R rs3772616多态性可作为ACI发生的潜在治疗靶点和生物指标。
