Guo Yang, Guo Jinjin, Zheng Dongming, Pan Lili, Li Qiang, Ruan Gang
Department of Neurology, the Second Clinical College, China Medical University, Shenyang, Liaoning, 110004 P. R. China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Jun;19(3):209-12.
OBJECTIVE To investigate the relationship between the Nco I, Ava II polymorphism of low density lipoprotein receptor (LDL-R) gene in patients with the occurrence of atherosclerotic cerebral infarction (ACI) among the Han nationality in Liaoning province. METHODS The polymerase chain reaction technique was used to study the polymorphisms of LDL-R gene and allele frequencies in 77 patients with ACI and in 113 age-matched Chinese healthy controls. The levels of the lipid and lipoproteins were also compared among the cases with ACI and the controls. RESULTS A(+) frequencies of LDL-R gene in healthy controls and ACI group were 0.230 and 0.125 respectively, while the N(+) frequencies of healthy control and ACI group was 0.667 and 0.662 respectively. In case of the coexistence of A(-) A(-) and N(+) N(+), the relative risk (RR) of ACI was 5.56(P<0.001), while the RR of the increase of serum levels TG, TC, LDL-C, LP(a) were 4.29, 7.67, 9.33 and 3.09(P<0.05), respectively. CONCLUSION The coexistence of A(-) A(-) and N(+) N(+) can affect the concentration of lipid and lipoprotein and is in close relationship with the occurrence of ACI.
目的 探讨辽宁省汉族人群中低密度脂蛋白受体（LDL-R）基因NcoⅠ、AvaⅡ多态性与动脉粥样硬化性脑梗死（ACI）发病的关系。方法 采用聚合酶链反应技术研究77例ACI患者及113例年龄匹配的中国健康对照者的LDL-R基因多态性及等位基因频率，并比较ACI患者与对照组的血脂及脂蛋白水平。结果 健康对照组和ACI组LDL-R基因A(+)频率分别为0.230和0.125，N(+)频率分别为0.667和0.662。在A(-)A(-)与N(+)N(+)共存的情况下，ACI的相对危险度（RR）为5.56（P<0.001），而血清TG、TC、LDL-C、LP(a)水平升高的RR分别为4.29、7.67、9.33和3.09（P<0.05）。结论 A(-)A(-)与N(+)N(+)共存可影响血脂及脂蛋白浓度，与ACI的发病密切相关。
