Ghafouri-Fard Soudeh, Khoshbakht Tayyebeh, Hussen Bashdar Mahmud, Jamal Hazha Hadayat, Taheri Mohammad, Hajiesmaeili Mohammadreza
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Oncol. 2022 May 2;12:870996. doi: 10.3389/fonc.2022.870996. eCollection 2022.
miR-15b-5p is encoded by gene. This gene is located on cytogenetic band 3q25.33. This miRNA participates in the pathogenesis of several cancers as well as non-malignant conditions, such as abdominal aortic aneurysm, Alzheimer's and Parkinson's diseases, cerebral ischemia reperfusion injury, coronary artery disease, dexamethasone induced steatosis, diabetic complications and doxorubicin-induced cardiotoxicity. In malignant conditions, both oncogenic and tumor suppressor impacts have been described for miR-15b-5p. Dysregulation of miR-15b-5p in clinical samples has been associated with poor outcome in different kinds of cancers. In this review, we discuss the role of miR-15b-5p in malignant and non-malignant conditions.
miR-15b-5p由基因编码。该基因位于细胞遗传学带3q25.33。这种微小RNA参与多种癌症以及非恶性疾病的发病机制，如腹主动脉瘤、阿尔茨海默病和帕金森病、脑缺血再灌注损伤、冠状动脉疾病、地塞米松诱导的脂肪变性、糖尿病并发症和阿霉素诱导的心脏毒性。在恶性疾病中，miR-15b-5p既有致癌作用，也有肿瘤抑制作用。临床样本中miR-15b-5p的失调与不同类型癌症的不良预后相关。在本综述中，我们讨论了miR-15b-5p在恶性和非恶性疾病中的作用。
