Materials Physics Department, Universidad Autónoma de Madrid (UAM), Avda. Francisco Tomás y Valiente, 7. 28049, Madrid, Spain.
CIC biomaGUNE, Basque Research and Technology Alliance (BRTA), Paseo de Miramón 194, 20014 Donostia-San Sebastián, Spain.
Chem Soc Rev. 2022 Jun 6;51(11):4223-4242. doi: 10.1039/d2cs00069e.
Temperature monitoring is useful in medical diagnosis, and essential during hyperthermia treatments to avoid undesired cytotoxic effects. Aiming to control heating doses, different temperature monitoring strategies have been developed, largely based on luminescent materials, a.k.a. nanothermometers. However, for such nanothermometers to work, both excitation and emission light beams must travel through tissue, making its optical properties a relevant aspect to be considered during the measurements. In complex tissues, heterogeneity, and real-time alterations as a result of therapeutic treatment may have an effect on light-tissue interaction, hindering accuracy in the thermal reading. In this Tutorial Review we discuss various methods in which nanothermometers can be used for temperature sensing within heterogeneous environments. We discuss recent developments in optical (nano)thermometry, focusing on the incorporation of luminescent nanoparticles into complex and models. Methods formulated to avoid thermal misreading are also discussed, considering their respective advantages and drawbacks.
温度监测在医学诊断中很有用，在高热治疗中也很重要，以避免不必要的细胞毒性作用。为了控制加热剂量，已经开发了不同的温度监测策略，主要基于发光材料，也称为纳米温度计。然而，为了使这些纳米温度计能够工作，激发和发射光束都必须穿过组织，因此在测量过程中必须考虑其光学性质。在复杂的组织中，异质性和治疗过程中的实时变化可能会对光-组织相互作用产生影响，从而影响热读数的准确性。在本教程综述中，我们讨论了纳米温度计在异质环境中用于温度传感的各种方法。我们讨论了光学（纳米）温度计的最新进展，重点介绍了将发光纳米粒子纳入复杂模型和模型的方法。还讨论了避免热误读的方法，考虑了它们各自的优缺点。
