Gerasimova Elena N, Fatkhutdinova Landysh I, Vazhenin Ivan I, Uvarov Egor I, Vysotina Elizaveta, Mikhailova Lidia, Lazareva Polina A, Kostyushev Dmitry, Abakumov Maxim, Parodi Alessandro, Yaroshenko Vitaly V, Zuev Dmitry A, Zyuzin Mikhail V
School of Physics and Engineering, ITMO University, Lomonosova 9, 191002 St. Petersburg, Russia.
Department of Medical Nanobiotechnology, N.I. Pirogov Russian National Research Medical University, Ostrovityanova 1 bldg. 6, 117997 Moscow, Russia.
Nanophotonics. 2024 Aug 28;13(22):4111-4125. doi: 10.1515/nanoph-2024-0285. eCollection 2024 Sep.
Hyperthermia plays a significant role in cancer treatment by inducing cell damage through temperature elevation, often used alongside other treatment modalities. During hyperthermia therapy, temperature control is crucial. Here, we report on a simple synthesis route of hybrid plasmonic nanodiamonds either completely wrapped with an Au shell () or densely covered with Au NPs ( ). Such integration of nanodiamonds with Au NPs is advantageous both for heating and precise thermometry at nanoscale. After structural and optical investigations, heating abilities of the obtained plasmonic nanodiamonds were thoroughly inspected on glass, in association with living cells, and in tissue slices , revealing their effective heat generation under excitation with light using a single excitation source. The developed hybrid plasmonic nanodiamonds were finally applied for local photothermal therapy of melanoma , demonstrating their efficacy in eradicating cancer cells and monitoring temperature during the process.
热疗通过升高温度诱导细胞损伤，在癌症治疗中发挥着重要作用，常与其他治疗方式联合使用。在热疗过程中，温度控制至关重要。在此，我们报道了一种简单的合成路线，用于制备完全包裹有金壳（）或密集覆盖有金纳米粒子（）的混合等离子体纳米金刚石。纳米金刚石与金纳米粒子的这种整合对于纳米级的加热和精确温度测量都具有优势。经过结构和光学研究后，在玻璃上、与活细胞一起以及在组织切片中对所获得的等离子体纳米金刚石的加热能力进行了全面检查，揭示了它们在使用单一激发源的光激发下能够有效产热。最终，将所开发的混合等离子体纳米金刚石应用于黑色素瘤的局部光热治疗，证明了它们在根除癌细胞和监测治疗过程中温度方面的功效。
