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对 BNT162b2 mRNA 疫苗的免疫反应的持久性。

Durability of immune responses to the BNT162b2 mRNA vaccine.

机构信息

Department of Pediatrics, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.

Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.

出版信息

Med. 2022 Jan 14;3(1):25-27. doi: 10.1016/j.medj.2021.12.005.

DOI:10.1016/j.medj.2021.12.005
PMID:35590141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9304003/
Abstract

Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination.

摘要

接种第二剂辉瑞-生物科技 mRNA 疫苗 6 个月后，针对该疫苗的抗体反应明显减弱。

相似文献

[1]
Durability of immune responses to the BNT162b2 mRNA vaccine.

Med. 2022-1-14

[2]
Dynamics of antibody titers and cellular immunity among Japanese healthcare workers during the 6 months after receiving two doses of BNT162b2 mRNA vaccine.

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[3]
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[4]
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[5]
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[6]
Kinetics and Persistence of the Cellular and Humoral Immune Responses to BNT162b2 mRNA Vaccine in SARS-CoV-2-Naive and -Experienced Subjects: Impact of Booster Dose and Breakthrough Infections.

Front Immunol. 2022

[7]
Elevated CD21 B Cell Frequency Is a Marker of Poor Immunity to Pfizer-BioNTech BNT162b2 mRNA Vaccine Against SARS-CoV-2 in Patients with Common Variable Immunodeficiency.

J Clin Immunol. 2022-5

[8]
T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study.

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[9]
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Microbiol Spectr. 2021-12-22

[10]
Humoral Responses Against Variants of Concern by COVID-19 mRNA Vaccines in Immunocompromised Patients.

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引用本文的文献

[1]
Humoral and Memory B Cell Responses Following SARS-CoV-2 Infection and mRNA Vaccination.

Vaccines (Basel). 2025-7-28

[2]
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[3]
A bovine adenoviral-vector-based universal influenza vaccine confers protection against influenza A and B viruses in mice and ferrets.

Mol Ther Nucleic Acids. 2025-6-9

[4]
A Big Data Optimization Approach for Estimating the Time-Dependent Effectiveness Profiles Against Hospitalization for Double- and Single-Dose Schemes: Study Case, COVID-19 in Elderly Mexicans.

Vaccines (Basel). 2025-3-28

[5]
SARS-CoV-2 vaccination in inflammatory bowel disease (IBD) patients - does treatment for IBD negatively affect SARS-CoV-2 antibodies? A single-centre, prospective study.

Prz Gastroenterol. 2024

[6]
Durability of immune responses to SARS-CoV-2 infection and vaccination.

Semin Immunol. 2024-5

[7]
SARS-CoV-2 booster vaccine dose significantly extends humoral immune response half-life beyond the primary series.

Sci Rep. 2024-4-18

[8]
AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans.

Sci Immunol. 2024-4-5

[9]
Prototype and BA.5 protein nanoparticle vaccines protect against Omicron BA.5 variant in Syrian hamsters.

J Virol. 2024-3-19

[10]
Mathematical Optimization Strategy for Effectiveness Profile Estimation in Two-Dose Vaccines and Its Use in Designing Improved Vaccination Strategies Focused on Pandemic Containment.

Vaccines (Basel). 2024-1-12

本文引用的文献

[1]
Waning Immunity after the BNT162b2 Vaccine in Israel.

N Engl J Med. 2021-12-9

[2]
Waning Immune Humoral Response to BNT162b2 Covid-19 Vaccine over 6 Months.

N Engl J Med. 2021-12-9

[3]
Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants.

Science. 2021-9-17

[4]
Systems vaccinology of the BNT162b2 mRNA vaccine in humans.

Nature. 2021-8

[5]
Longitudinal analysis shows durable and broad immune memory after SARS-CoV-2 infection with persisting antibody responses and memory B and T cells.

Cell Rep Med. 2021-7-20

[6]
Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19.

N Engl J Med. 2021-6-10

[7]
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies.

Cell. 2021-4-29

[8]
Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS-CoV-2 Neutralizing Antibodies.

Curr Protoc Immunol. 2020-12

[9]
Heterogeneity and longevity of antibody memory to viruses and vaccines.

PLoS Biol. 2018-8-10

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