对 BNT162b2 mRNA 疫苗的免疫反应的持久性。
Durability of immune responses to the BNT162b2 mRNA vaccine.
机构信息
Department of Pediatrics, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University School of Medicine, Atlanta, GA, USA.
Institute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.
出版信息
Med. 2022 Jan 14;3(1):25-27. doi: 10.1016/j.medj.2021.12.005.
Abstract
Antibody responses to the Pfizer-BioNTech mRNA vaccine waned substantially 6 months after the second vaccination.
摘要
接种第二剂辉瑞-生物科技 mRNA 疫苗 6 个月后，针对该疫苗的抗体反应明显减弱。
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3
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4
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