杂交肽核酸两亲分子的自组装

Self-Assembly of Hybridized Peptide Nucleic Acid Amphiphiles.

作者信息

Liu Li-Han, Li Ze-Yong, Rong Lei, Qin Si-Yong, Lei Qi, Cheng Han, Zhou Xiang, Zhuo Ren-Xi, Zhang Xian-Zheng

机构信息

Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry, Wuhan University, Wuhan 430072, China.

出版信息

ACS Macro Lett. 2014 May 20;3(5):467-471. doi: 10.1021/mz5001916. Epub 2014 May 6.

DOI:10.1021/mz5001916

PMID:35590784

Abstract

In this report, a series of peptide nucleic acid amphiphiles (PNAAs) with hybridization properties were designed and synthesized. Driven by hydrophobic interaction, the hybridized PNAAs can form uniform micelles, the base stacking interaction from PNA segments further stabilized the micelles. The effects of hydrophobic alkyl chain length, structure of hydrophilic peptides, concentration, and pH on the self-assembly behavior of partly complementing PNAA duplexes were explored.

摘要

在本报告中，设计并合成了一系列具有杂交特性的肽核酸两亲物（PNAA）。在疏水相互作用的驱动下，杂交后的PNAA可以形成均匀的胶束，PNA片段的碱基堆积相互作用进一步稳定了胶束。研究了疏水烷基链长度、亲水性肽的结构、浓度和pH对部分互补PNAA双链体自组装行为的影响。