Istituto di Scienze e Tecnologie Chimiche "Giulio Natta", Consiglio Nazionale delle Ricerche, Via M. Bianco 9, 20131 Milan, Italy.
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via G. Venezian 21, 20133 Milan, Italy.
Int J Mol Sci. 2024 Nov 19;25(22):12435. doi: 10.3390/ijms252212435.
Obtaining new materials by exploiting the self-assembly of biomolecules is a very challenging field. In recent years, short peptides and nucleic acids have been used as scaffolds to produce supramolecular structures for different applications in the biomedical and technological fields. In this review, we will focus on the self-assembly of peptide nucleic acids (PNAs), their conjugates with peptides, or other molecules. We will describe the physical properties of the assembled systems and, where described, the application they were designed for.
通过利用生物分子的自组装来获得新材料是一个极具挑战性的领域。近年来，短肽和核酸已被用作支架，以在生物医学和技术领域的不同应用中产生超分子结构。在这篇综述中，我们将重点介绍肽核酸（PNAs）的自组装、它们与肽或其他分子的缀合物。我们将描述组装系统的物理性质，并在有描述的情况下，介绍它们的设计应用。
