Read S G, Batchelor D H
Int Clin Psychopharmacol. 1986 Jul;1 Suppl 1:63-74.
Aggressive and self-destructive behaviour in mentally handicapped patients presents the psychiatrist with formidable problems, especially in the diagnosis of specific mental disorders using the criteria of current classificatory systems. Having reviewed the use of antidepressants, antianxiety agents and the wide range of oral antipsychotics previously employed, the literature describing treatment with depot neuroleptics is considered. The results of switching twenty-one patients to the depot butyrophenone haloperidol decanoate, dose range 50 to 300 mg given four-weekly over a nine month period, are described: they confirm previous observations that the "knock-on" effect of disruptive behaviour and the overall level of violence and self-injury can be considerably reduced when only some of the patients in any one ward are adequately treated.
智障患者的攻击和自我毁灭行为给精神科医生带来了巨大的问题，尤其是在使用当前分类系统的标准诊断特定精神障碍时。在回顾了抗抑郁药、抗焦虑药以及先前使用的各种口服抗精神病药的使用情况后，本文考虑了有关长效抗精神病药物治疗的文献。文中描述了将21名患者改用长效丁酰苯氟哌啶醇癸酸酯的结果，剂量范围为50至300毫克，每四周给药一次，为期九个月：这些结果证实了先前的观察结果，即当任何一个病房中只有部分患者得到充分治疗时，破坏性行为的“连锁反应”以及暴力和自我伤害的总体水平可大幅降低。
