Alam Walid, Mohamad Rayan, Koubaissi Maysoun, Koubaissi Salwa A
Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Pulmonary and Critical Care Division, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Clin Med Insights Case Rep. 2022 May 13;15:11795476221097317. doi: 10.1177/11795476221097317. eCollection 2022.
Pulmonary complications post hematopoietic stem cell transplant (HSCT) are associated with poor outcomes and require extensive management depending on the etiology. They usually present in the form of bronchiolitis obliterans syndrome, interstitial pneumonitis, or drug toxicity that can lead to fibrosis. Scant data exists regarding diffuse cystic lung disease following HSCT, and the existing literature only mentions mild cystic changes. We present the case of a 25-year-old man with stage IVB Hodgkin's lymphoma post allogeneic HSCT, who developed progressive traction bronchiectasis, with the appearance of extensive pulmonary cysts that followed significant fibrotic changes and discuss the possible etiologies behind it.
造血干细胞移植（HSCT）后的肺部并发症与不良预后相关，需要根据病因进行广泛的管理。它们通常表现为闭塞性细支气管炎综合征、间质性肺炎或可导致纤维化的药物毒性。关于HSCT后弥漫性囊性肺病的数据很少，现有文献仅提及轻度囊性改变。我们报告了一例25岁男性，在接受异基因HSCT后患有IVB期霍奇金淋巴瘤，出现进行性牵拉性支气管扩张，并伴有广泛肺囊肿，这些囊肿在显著纤维化改变后出现，并讨论其背后可能的病因。
