布法罗骨与牙周研究：我们的研究结果总结以及罗伯特·J·根科博士（牙医学博士、哲学博士）的独特贡献
The Buffalo OsteoPerio Studies: Summary of our findings and the unique contributions of Robert J. Genco, DDS, PhD.
作者信息
Wactawski-Wende Jean, LaMonte Michael J, Hovey Kathy, Banack Hailey
机构信息
Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo.
出版信息
Curr Oral Health Rep. 2020 Mar;7(1):29-36. doi: 10.1007/s40496-020-00257-3. Epub 2020 Jan 27.
PURPOSE
Robert ("Bob") Genco was a member of the research team that established the Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) study. Here we detail the scientific discoveries emanating from this enduring collaboration.
STUDY COHORTS
OsteoPerio is ancillary to the Women's Health Initiative Observational Study (WHI-OS). WHI-OS is a longitudinal study of 93,000 postmenopausal women aged 50-79 enrolled at 40 U.S. centers (enrolled 1993-1998). OsteoPerio enrolled 1342 women 3 years later (1997-2001) from the Buffalo WHI-OS participants to study the association of osteoporosis and periodontal disease. OsteoPerio has 5-year (N=1026) and 17-year (N=518) follow-up examinations.
PARTICIPANTS
In addition to information on health status from the WHI-OS, OsteoPerio further included comprehensive oral examinations assessing probing pocket depth, clinical attachment loss, gingival bleeding, alveolar crestal height, and DMFT. Systemic bone density (measured by DXA), blood, saliva and plaque also were collected at all three visits.
SUMMARY
Findings from these studies are summarized here.
目的
罗伯特（“鲍勃”）·根科是建立布法罗骨质疏松症与牙周疾病（OsteoPerio）研究的研究团队成员。在此，我们详细介绍这一长期合作所产生的科学发现。
研究队列
OsteoPerio是妇女健康倡议观察性研究（WHI-OS）的附属研究。WHI-OS是一项对93000名年龄在50至79岁的绝经后妇女进行的纵向研究，这些妇女在美国40个中心入组（1993年至1998年入组）。三年后（1997年至2001年），OsteoPerio从布法罗WHI-OS的参与者中招募了1342名女性，以研究骨质疏松症与牙周疾病之间的关联。OsteoPerio进行了为期5年（N = 1026）和17年（N = 518）的随访检查。
参与者
除了来自WHI-OS的健康状况信息外，OsteoPerio还进一步进行了全面的口腔检查，评估探诊深度、临床附着丧失、牙龈出血、牙槽嵴高度和龋失补牙数。在所有三次就诊时还收集了全身骨密度（通过双能X线吸收法测量）、血液、唾液和牙菌斑。
总结
这些研究的结果在此进行总结。
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