Department of Emergency Medicine, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Chronic Kidney Disease Research Center (CKDRC), Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Biomed Res Int. 2022 May 10;2022:2350063. doi: 10.1155/2022/2350063. eCollection 2022.
The outbreak of coronavirus disease 2019 (COVID-19) dates back to December 2019 in China. Iran has been among the most prone countries to the virus. The aim of this study was to report demographics, clinical data, and their association with death and CFR.
This observational cohort study was performed from 20th March 2020 to 18th March 2021 in three tertiary educational hospitals in Tehran, Iran. All patients were admitted based on the WHO, CDC, and Iran's National Guidelines. Their information was recorded in their medical files. Multivariable analysis was performed to assess demographics, clinical profile, outcomes of disease, and finding the predictors of death due to COVID-19.
Of all 5318 participants, the median age was 60.0 years, and 57.2% of patients were male. The most significant comorbidities were hypertension and diabetes mellitus. Cough, dyspnea, and fever were the most dominant symptoms. Results showed that ICU admission, elderly age, decreased consciousness, low BMI, HTN, IHD, CVA, dialysis, intubation, Alzheimer disease, blood injection, injection of platelets or FFP, and high number of comorbidities were associated with a higher risk of death related to COVID-19. The trend of CFR was increasing (WPC: 1.86) during weeks 25 to 51.
Accurate detection of predictors of poor outcomes helps healthcare providers in stratifying patients, based on their risk factors and healthcare requirements to improve their survival chance.
2019 年冠状病毒病（COVID-19）的爆发可追溯到中国 2019 年 12 月。伊朗是最容易感染该病毒的国家之一。本研究旨在报告人口统计学、临床数据及其与死亡和病死率的关系。
本观察性队列研究于 2020 年 3 月 20 日至 2021 年 3 月 18 日在伊朗德黑兰的三家三级教育医院进行。所有患者均根据世界卫生组织、疾病预防控制中心和伊朗国家指南入院。他们的信息记录在他们的病历中。进行多变量分析以评估人口统计学、临床特征、疾病结局以及发现 COVID-19 死亡的预测因素。
在所有 5318 名参与者中，中位年龄为 60.0 岁，57.2%的患者为男性。最常见的合并症是高血压和糖尿病。咳嗽、呼吸困难和发热是最常见的症状。结果表明，入住重症监护病房、年龄较大、意识下降、低体重指数、高血压、缺血性心脏病、中风、透析、插管、阿尔茨海默病、血液输注、血小板或 FFP 输注以及合并症数量较多与 COVID-19 相关死亡风险增加相关。CFR 的趋势在第 25 周至第 51 周期间呈上升趋势（WPC：1.86）。
准确检测不良结局的预测因素有助于医疗保健提供者根据患者的危险因素和医疗保健需求对患者进行分层，以提高他们的生存机会。
