Department of Urology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Department of Pharmacy, The First Affiliated Hospital of Soochow University, Suzhou, China.
Adv Exp Med Biol. 2022;1368:1-19. doi: 10.1007/978-981-16-8969-7_1.
Virus infection is a common social health issue. In the past decades, serious virus infectious events have caused great loss in people's life and the economics. The nature of rapid widespread and frequent variation increases the difficulty for precision viral prevention and treatment. In the era of big data and artificial intelligence (AI), advances in bioinformatics techniques bring unprecedented opportunities for virus informatics study, which contribute to the systems-level modeling of virus biology. In this chapter, data resources including virus-related databases and knowledgebases are introduced. Bioinformatics models and software tools for multiple sequence alignment, evolutionary analysis, and genome-wide research of viruses are summarized and emphasized. Translational applications of recently developed data-driven and AI-assisted methods to viral cases such as SARS-CoV-2, HBV/HCV, and influenza virus are discussed. Finally, the concept and significance of virus informatics are highlighted for both virus surveillance and health promotion.
病毒感染是一个常见的社会健康问题。在过去几十年中，严重的病毒感染事件给人们的生命和经济造成了巨大损失。病毒快速广泛和频繁变异的特性增加了精准防治的难度。在大数据和人工智能（AI）时代，生物信息学技术的进步为病毒信息学研究带来了前所未有的机遇，有助于对病毒生物学进行系统级建模。在本章中，介绍了包括病毒相关数据库和知识库在内的数据资源。总结并强调了用于多序列比对、进化分析和病毒全基因组研究的生物信息学模型和软件工具。讨论了最近开发的数据驱动和 AI 辅助方法在 SARS-CoV-2、HBV/HCV 和流感病毒等病毒病例中的转化应用。最后，强调了病毒信息学在病毒监测和促进健康方面的概念和意义。
