病毒的起源和进化的生物信息学。

Bioinformatics for the Origin and Evolution of Viruses.

机构信息

School of Chemistry and Life Science, Suzhou University of Science and Technology, Suzhou, Jiangsu, China.

Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

出版信息

Adv Exp Med Biol. 2022;1368:53-71. doi: 10.1007/978-981-16-8969-7_3.

DOI:10.1007/978-981-16-8969-7_3

PMID:35594020

Abstract

The ongoing pandemic of coronavirus disease 2019 (COVID19) caused by infection with human SARS-CoV-2 is a global threat to the human population. World effort has arisen toward the characterization of the origin and evolutionary features of this devastating virus. The development of high-throughput sequencing platforms has facilitated the surveillance of viral sequence diversity in both human and animal populations. Bioinformatics pipelines are readily available for ongoing virus tracking on a global level. In this chapter, we summarize the bioinformatics tools in the origin tracing and evolutionary analyses of viruses with a highlight in their application in SARS-CoV-2, which will facilitate the prevention of the pandemic as well as custom-designed antiviral strategies.

摘要

由人类严重急性呼吸系统综合征冠状病毒 2 型（SARS-CoV-2）感染引起的 2019 年冠状病毒病（COVID19）疫情是对全球人口的全球性威胁。为了描述这种具有破坏性的病毒的起源和进化特征，全世界都做出了努力。高通量测序平台的发展促进了人类和动物群体中病毒序列多样性的监测。生物信息学管道可用于在全球范围内进行病毒的实时跟踪。在本章中，我们总结了病毒起源追踪和进化分析的生物信息学工具，重点介绍了它们在 SARS-CoV-2 中的应用，这将有助于预防大流行以及定制抗病毒策略。