与疟疾暴露相关的1型人类免疫缺陷病毒易感性：一项病例对照研究。

Susceptibility to Human Immunodeficiency Virus Type 1 Acquisition Linked to Malaria Exposure: A Case-Control Study.

作者信息

Kamau Edwin, Chaudhury Sidhartha, Bolton Jessica S, Slike Bonnie M, Jian Ningbo, Eller Michael A, Eller Leigh Anne, Ake Julie, Robb Merlin L, Krebs Shelly J, Bergmann-Leitner Elke S

机构信息

United States. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.

出版信息

Clin Infect Dis. 2022 Nov 14;75(10):1834-1837. doi: 10.1093/cid/ciac384.

DOI:10.1093/cid/ciac384

PMID:35594548

Abstract

Human immunodeficiency virus (HIV) and malaria infection rates overlap across sub-Saharan Africa, but factors influencing their co-occurrence are unclear. In a case-control study, we investigated whether malaria exposure increases risk of type 1 (HIV-1) acquisition. Prior to seroconverting, HIV-positive cases had significantly higher malaria-associated antibodies compared to HIV-negative controls, linking malaria exposure to HIV-1 acquisition.

摘要

在撒哈拉以南非洲地区，人类免疫缺陷病毒（HIV）和疟疾的感染率存在重叠，但影响二者同时出现的因素尚不清楚。在一项病例对照研究中，我们调查了接触疟疾是否会增加感染1型人类免疫缺陷病毒（HIV-1）的风险。在血清转化之前，与HIV阴性对照组相比，HIV阳性病例的疟疾相关抗体水平显著更高，这表明接触疟疾与感染HIV-1有关。