全基因组关联研究鉴定了与约克夏猪的饲料转化率和剩余采食量都相关的位点。

Genome-wide association studies identified loci associated with both feed conversion ratio and residual feed intake in Yorkshire pigs.

机构信息

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan 611130, China.

Chongqing Academy of Animal Science, Chongqing, Chongqing 402460, China.

出版信息

Genome. 2022 Jul 1;65(7):405-412. doi: 10.1139/gen-2021-0105. Epub 2022 May 20.

DOI:10.1139/gen-2021-0105

PMID:35594567

Abstract

Feed occupies a significant proportion in the production cost of pigs, and the feed efficiency (FE) in pigs is of utmost economic importance. Hence, the objective of this study is to identify single-nucleotide polymorphisms (SNPs) and candidate genes associated with FE-related traits, including feed conversion ratio (FCR) and residual feed intake (RFI). A genome-wide association study was conducted for FCR and RFI in 169 Yorkshire pigs using whole-genome sequencing data. A total of 23 and 33 suggestive significant SNPs ( < 1 × 10) were detected for FCR and RFI, respectively. However, none of SNPs achieved the genome-wide significance threshold ( < 5 × 10). Importantly, three common SNPs (SSC7:7987268, SSC13:42350250, and SSC13:42551718) were associated with both FCR and RFI. Additionally, the gene related to FCR and RFI traits was overlapped. This study detected novel SNPs on SSC7 and SSC13 common for FCR and RFI. These results provide new insights into the genetic mechanisms and candidate genes of FE-related traits in pigs.

摘要

饲料在猪的生产成本中占据重要比例，而猪的饲料效率（FE）具有至关重要的经济意义。因此，本研究旨在鉴定与 FE 相关性状（包括饲料转化率（FCR）和剩余饲料摄入量（RFI））相关的单核苷酸多态性（SNP）和候选基因。使用全基因组测序数据，对 169 头约克夏猪的 FCR 和 RFI 进行了全基因组关联研究。分别检测到与 FCR 和 RFI 相关的 23 个和 33 个提示性显著 SNP（<1×10）。然而，没有一个 SNP 达到全基因组显著阈值（<5×10）。重要的是，三个常见 SNP（SSC7：7987268、SSC13：42350250 和 SSC13：42551718）与 FCR 和 RFI 均相关。此外，与 FCR 和 RFI 性状相关的基因存在重叠。本研究在 SSC7 和 SSC13 上检测到与 FCR 和 RFI 共同的新 SNP。这些结果为猪 FE 相关性状的遗传机制和候选基因提供了新的见解。