Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Infantile Sciences (DINOGMI), University of Genova, Campus of Savona, SV, Italy.
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Infantile Sciences (DINOGMI), University of Genova, Campus of Savona, SV, Italy.
Musculoskelet Sci Pract. 2022 Aug;60:102570. doi: 10.1016/j.msksp.2022.102570. Epub 2022 Apr 29.
Recent studies found that fibromyalgia may underly neuropathic conditions affecting the peripheral nervous system. Moreover, clinical observations and preliminary reports suggest the existence of body perceptions distortions (BPD) like "phantom" feelings of swollen hands and feet, similar to those complained by patients with other neuropathic conditions or subjected to experimental procedures affecting the peripheral nervous system.
To investigate the prevalence of self-reported BPD in Italian people with fibromyalgia through an online survey administered with the help of the associations of patients distributed nationwide.
cross-sectional study.
A nationwide sample of 854 patients out of 1173 subjects enrolled was analyzed after the exclusion of comorbidities and incomplete answers. We additionally performed a post-hoc analysis comparing data of patients who entirely fulfilled the Fibromyalgia Research Criteria (FRC) (2011) for epidemiological studies with respect to those only partially responding to the FRC (FM-).
Nearly 90% of subjects reported neuropathic pain, symptoms potentially indicative for small-fiber pathology, and at least 1 BPD, while 2 or more BPD was reported in 64.1% of cases. Phantom feelings of "heaviness", "constriction", and "swelling" were the most frequently self-reported perceptual distortions. BPD were significant correlated with symptoms potentially indicative for small-fiber pathology, neuropathic pain, disability, painful sites, and severity of fibromyalgia (0.20<τ-b<0.33).
Our preliminary findings highlighted that the phenomenon of self-reported BPD in patients with fibromyalgia correlated with neuropathic symptoms. If these results will be confirmed in future studies BPD may be potentially considered as part of the clinical picture of fibromyalgia.
最近的研究发现，纤维肌痛可能是影响周围神经系统的神经病理性疾病的基础。此外，临床观察和初步报告表明存在身体知觉扭曲（BPD），如“幻肢”肿胀感，类似于其他神经病理性疾病患者或经历影响周围神经系统的实验程序的患者所抱怨的。
通过全国性患者协会协助进行的在线调查，研究意大利纤维肌痛患者自我报告的 BPD 患病率。
横断面研究。
排除合并症和不完整答案后，对全国范围内招募的 1173 名受试者中的 854 名患者进行了分析。我们还进行了事后分析，比较了完全符合纤维肌痛研究标准（2011 年）的患者数据与仅部分符合纤维肌痛研究标准（FM-）的患者数据。
近 90%的患者报告有神经病理性疼痛、小纤维病变的潜在症状和至少 1 种 BPD，而 64.1%的患者报告了 2 种或更多的 BPD。“沉重感”、“紧缩感”和“肿胀感”是最常报告的知觉扭曲。BPD 与小纤维病变的潜在症状、神经病理性疼痛、残疾、疼痛部位和纤维肌痛的严重程度显著相关（0.20<τ-b<0.33）。
我们的初步发现强调了纤维肌痛患者自我报告的 BPD 现象与神经病理性症状相关。如果这些结果在未来的研究中得到证实，BPD 可能被视为纤维肌痛临床特征的一部分。
