School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Biomed Pharmacother. 2022 Jul;151:113107. doi: 10.1016/j.biopha.2022.113107. Epub 2022 May 16.
Coronavirus disease 2019 (COVID-19) is a viral disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a member of the Coronaviridae family. On March 11, 2020 the World Health Organization (WHO) has named the newly emerged rapidly-spreading epidemic as a pandemic. Besides the risk-reduction measures such as physical and social distancing and vaccination, a wide range of treatment modalities have been developed; aiming to fight the disease. The immune system is known as a double-edged sword in COVID-19 pathogenesis, with respect to its role in eliminating the pathogen and in inducing complications such as cytokine storm syndrome. Hence, immune-based therapeutic approaches have become an interesting field of COVID-19 research, including corticosteroids, intravenous immunoglobulins (IVIG), interferon therapy, and more COVID-19-specific approaches such as anti-SARS-CoV-2-monoclonal antibodies. Herein, we did a comprehensive review on immune-based therapeutic approaches for COVID-19. DATA AVAILABILITY STATEMENT: Not applicable.
2019 冠状病毒病（COVID-19）是由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的病毒性疾病，该病毒属于冠状病毒科。2020 年 3 月 11 日，世界卫生组织（WHO）已将新出现的迅速传播的传染病命名为大流行。除了物理和社会隔离以及接种疫苗等降低风险的措施外，还开发了多种治疗方法；旨在对抗疾病。免疫系统在 COVID-19 发病机制中被称为双刃剑，它在消除病原体和诱导细胞因子风暴综合征等并发症方面发挥作用。因此，基于免疫的治疗方法已成为 COVID-19 研究的一个有趣领域，包括皮质类固醇、静脉注射免疫球蛋白（IVIG）、干扰素治疗等，以及更针对 COVID-19 的方法，如抗 SARS-CoV-2 单克隆抗体。在此，我们对 COVID-19 的基于免疫的治疗方法进行了全面综述。数据可用性声明：不适用。
